Artículo
Chitosan microparticles: influence of the gelation process on the release profile and oral bioavailability of albendazole, a class II compound
Piccirilli, Gisela Noemi
; García, Agustina
; Leonardi, Darío
; Mamprin, María Eugenia
; Bolmaro, Raul Eduardo
; Salomon, Claudio Javier
; Lamas, Maria Celina
Fecha de publicación:
08/2013
Editorial:
Taylor & Francis
Revista:
Drug Development and Industrial Pharmacy
ISSN:
0363-9045
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Encapsulation of albendazole, a class II compound, into polymeric microparticles based on chitosan-sodium lauryl sulfate was investigated as a strategy to improve drug dissolution and oral bioavailability. The microparticles were prepared by spray drying technique and further characterized by means of X-ray powder diffractometry, infrared spectroscopy and scanning electron microscopy. The formation of a novel polymeric structure between chitosan and sodium lauryl sulfate, after the internal or external gelation process, was observed by infrared spectroscopy. The efficiency of encapsulation was found to be between 60 and 85% depending on the internal or external gelation process. Almost spherically spray dried microparticles were observed using scanning electron microscopy. In vitro dissolution results indicated that the microparticles prepared by internal gelation released 8% of the drug within 30 min, while the microparticles prepared by external gelation released 67% within 30 min. It was observed that the AUC and Cmax values of ABZ from microparticles were greatly improved, in comparison with the non-encapsulated drug. In conclusion, the release properties and oral bioavailability of albendazole were greatly improved by using spraydried chitosan-sodium lauryl sulphate microparticles.
Palabras clave:
Albendazole
,
Bioavailability
,
Chitosan
,
Dissolution Rate
,
Microparticles
Archivos asociados
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Identificadores
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos(IFIR)
Articulos de INST.DE FISICA DE ROSARIO (I)
Articulos de INST.DE FISICA DE ROSARIO (I)
Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Articulos de INST.DE QUIMICA ROSARIO
Citación
Piccirilli, Gisela Noemi; García, Agustina; Leonardi, Darío; Mamprin, María Eugenia; Bolmaro, Raul Eduardo; et al.; Chitosan microparticles: influence of the gelation process on the release profile and oral bioavailability of albendazole, a class II compound; Taylor & Francis; Drug Development and Industrial Pharmacy; 40; 11; 8-2013; 1476-1482
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