Artículo
BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development
Díaz, Pablo Uriel
; Hein, Gustavo Juan
; Belotti, Eduardo Matías
; Rodríguez, Fernanda Mariel
; Rey, Florencia
; Amweg, Ayelen Noelia
; Matiller, Valentina
; Baravalle, María Eugenia
; Ortega, Hugo Hector
; Salvetti, Natalia Raquel
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Fecha de publicación:
10/2016
Editorial:
BioScientifica
Revista:
Reproduction
ISSN:
1470-1626
e-ISSN:
1741-7899
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Cystic ovarian disease (COD) is an important cause of subfertility in dairy cattle. Bone morphogenetic proteins (BMPs), mainly BMP2, BMP4 and BMP6, play a key role in female fertility. In this study, we hypothesized that an altered BMP system is associated with ovarian alterations contributing to COD pathogenesis. Therefore, we examined the expression of BMP2, BMP4 and BMP6 and BMP receptor 1B (BMPR1B) in the ovaries of animals with spontaneous or ACTH-induced COD, as well as during the development of the disease, in a model of follicular persistence induced by low doses of progesterone (at 5, 10 and 15 days of follicular persistence). Results showed changes in BMP2, BMP4 and BMP6 expression during folliculogenesis, in granulosa and theca cells in the COD groups, as well as at different stages of follicular persistence. Results also showed changes in BMPR1B expression in developing follicles in animals with COD, and at the initial stages of follicular persistence (P5). Comparison between groups showed significant differences, mainly in BMP4 and BMP6 expression, in granulosa and theca cells of different follicular categories. The expression of these BMPs also increased in cystic and persistent follicles, in relation to antral follicles of the control group. BMPR1B showed high expression in cystic follicles. Together, these results may indicate an alteration in BMPs, especially in BMP4 and BMP6, as well as in BMPR1B, which occurs early in folliculogenesis and incipiently during the development of COD, which could be a major cause of recurrence of this disease in cattle.
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Articulos(ICIVET-LITORAL)
Articulos de INST. DE CIENCIAS VETERINARIAS DEL LITORAL
Articulos de INST. DE CIENCIAS VETERINARIAS DEL LITORAL
Citación
Díaz, Pablo Uriel; Hein, Gustavo Juan; Belotti, Eduardo Matías; Rodríguez, Fernanda Mariel; Rey, Florencia; et al.; BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development; BioScientifica; Reproduction; 152; 4; 10-2016; 333-350
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