Artículo
The RNA Response to DNA Damage
Giono, Luciana Eugenia
; Nieto Moreno, Nicolás
; Cambindo Botto, Adrian Edgardo
; Dujardin, Gwendal; Muñoz, Manuel Javier
; Kornblihtt, Alberto Rodolfo
Fecha de publicación:
06/2016
Editorial:
Academic Press Ltd - Elsevier Science Ltd
Revista:
Journal Of Molecular Biology
ISSN:
0022-2836
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, cell cycle arrest, senescence, and apoptosis. This entails regulation of a variety of cellular processes: DNA replication and transcription, RNA processing, mRNA translation and turnover, and post-translational modification, degradation, and relocalization of proteins. Accumulated evidence over the past decades has shown that RNAs and RNA metabolism are both regulators and regulated actors of the DDR. This review aims to present a comprehensive overview of the current knowledge on the many interactions between the DNA damage and RNA fields.
Palabras clave:
Alternative Splicing
,
Dna Damage Response
,
Ncrnas
,
P53
,
Rna Processing
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Identificadores
Colecciones
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Giono, Luciana Eugenia; Nieto Moreno, Nicolás; Cambindo Botto, Adrian Edgardo; Dujardin, Gwendal; Muñoz, Manuel Javier; et al.; The RNA Response to DNA Damage; Academic Press Ltd - Elsevier Science Ltd; Journal Of Molecular Biology; 428; 12; 6-2016; 2636-2651
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