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Artículo

NF-κB transcription factor role in consolidation and reconsolidation of persistent memories

de la Fuente, VerónicaIcon ; Federman, Maria NoelIcon ; Zalcman, Gisela PatriciaIcon ; Salles, AngelesIcon ; Freudenthal, Ramiro A. M.Icon ; Romano, Arturo GabrielIcon
Fecha de publicación: 09/2015
Editorial: Frontiers Research Foundation
Revista: Frontiers in Molecular Neuroscience
ISSN: 1662-5099
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Transcriptional regulation is an important molecular process required for long-term neural plasticity and long-term memory (LTM) formation. Thus, one main interest in molecular neuroscience in the last decades has been the identification of transcription factors that are involved in memory processes. Among them, the nuclear factor κB (NF-κB) family of transcription factors has gained interest due to a significant body of evidence that supports a key role of these proteins in synaptic plasticity and memory. In recent years, the interest was particularly reinforced because NF-κB was characterized as an important regulator of synaptogenesis. This function may be explained by its participation in synapse to nucleus communication, as well as a possible local role at the synapse. This review provides an overview of experimental work obtained in the last years, showing the essential role of this transcription factor in memory processes in different learning tasks in mammals. We focus the review on the consolidation and reconsolidation memory phases as well as on the regulation of immediate-early and late genes by epigenetic mechanisms that determine enduring forms of memories.
Palabras clave: Consolidation , Memory , Nf-Κb , Reconsolidation , Transcription Factors
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/60618
DOI: http://dx.doi.org/10.3389/fnmol.2015.00050
URL: https://www.frontiersin.org/articles/10.3389/fnmol.2015.00050/full
Colecciones
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
de la Fuente, Verónica; Federman, Maria Noel; Zalcman, Gisela Patricia; Salles, Angeles; Freudenthal, Ramiro A. M.; et al.; NF-κB transcription factor role in consolidation and reconsolidation of persistent memories; Frontiers Research Foundation; Frontiers in Molecular Neuroscience; 8; 50; 9-2015; 1-9
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