In vitro anticancer activity and SAR studies of triazolyl aminoacyl(peptidyl) penicillins

A library of triazolyl aminoacyl(peptidyl) penicillins was designed, synthesized, and evaluated for their antiproliferative activity against HeLa and B16-F0 cell lines. Structure–activity relationship studies were carried out, and minimal structural requirements were determined. Among the tested compounds, derivatives 7f, 7p and 7m demonstrated the highest anticancer activity and a promising selectivity profile against these two cell lines.

Palabras clave: Anticancer Activity , Sar Studies , Click Chemistry , Triazolyl Aminoacyl(Peptidyl) Penicillins

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/6056

URL: http://pubs.rsc.org/en/content/articlelanding/2014/md/c3md00332a

DOI: http://dx.doi.org/10.1039/C3MD00332A

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Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"

Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO

Citación

Cornier, Patricia Griselda; Delpiccolo, Carina Maria Lujan; Mascali, Florencia Carla; Boggian, Dora Bernarda; Mata, Ernesto Gabino; et al.; In vitro anticancer activity and SAR studies of triazolyl aminoacyl(peptidyl) penicillins; Royal Society of Chemistry; Medicinal Chemistry Communication; 5; 2; 12-2013; 214-218

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