Mostrar el registro sencillo del ítem

dc.contributor.author
García, Agustina
dc.contributor.author
Leonardi, Darío
dc.contributor.author
Vasconi, Ruben Luis
dc.contributor.author
Hinrichsen, Lucila Isabel
dc.contributor.author
Lamas, Maria Celina
dc.date.available
2016-06-03T21:39:26Z
dc.date.issued
2014-11
dc.identifier.citation
García, Agustina; Leonardi, Darío; Vasconi, Ruben Luis; Hinrichsen, Lucila Isabel; Lamas, Maria Celina; Characterization of Albendazole-Randomly Methylated-beta-Cyclodextrin Inclusion Complex and In Vivo Evaluation of Its Antihelmitic Activity in a Murine Model of Trichinellosis; Public Library of Science; Plos One; 9; 11; 11-2014; 1-7
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/6049
dc.description.abstract
Albendazole is a benzimidazole carbamate extensively used in oral chemotherapy against intestinal parasites, due to its broad spectrum activity, good tolerance and low cost. However, the drug has the disadvantage of poor bioavailability due to its very low solubility in water; as a consequence, a very active area of research focuses on the development of new pharmaceutical formulations to increase its solubility, dissolution rate, and bioavailability. The primary objective of this study was to prepare randomly methylated beta-cyclodextrins inclusion complexes to increase albendazole dissolution rate, in order to enhance its antiparasitic activity. This formulation therapeutic efficacy was contrasted with that of the pure drug by treating Trichinella spiralis infected mice during the intestinal phase of the parasite cycle, on days five and six post-infection. This protocol significantly decreased muscle larval burden measured in the parenteral stage on day 30 post-infection, when compared with the untreated control. Thus, it could be demonstrated that the inclusion complexes improve the in vivo therapeutic activity of albendazole.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Methylated-B-Cyclodextrin
dc.subject
Albendazole
dc.subject
Inclusion Complex
dc.subject
Trichinellosis
dc.subject.classification
Parasitología
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Farmacología y Farmacia
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Characterization of Albendazole-Randomly Methylated-beta-Cyclodextrin Inclusion Complex and In Vivo Evaluation of Its Antihelmitic Activity in a Murine Model of Trichinellosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-01T14:03:58Z
dc.journal.volume
9
dc.journal.number
11
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: García, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Vasconi, Ruben Luis. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Hinrichsen, Lucila Isabel. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Lamas, Maria Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario; Argentina
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113296
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1371%2Fjournal.pone.0113296
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236198/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/PMC4236198
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371%2Fjournal.pone.0113296


Archivos asociados

 

Comunidades y colecciones

Mostrar el registro sencillo del ítem