Artículo
Endoplasmic reticulum-localized hepatic lipase decreases triacylglycerol storage and VLDL secretion
Erickson, Bruce; Selvan, Senthamil Paramadayalan; Ko, Kerry W. S.; Kelly, Karen; Quiroga, Ariel Dario
; Li, Lena; Nelson, Randy; King Jones, Kirst; Jacobs, René L.; Lehner, Richard
Fecha de publicación:
06/2013
Editorial:
Elsevier
Revista:
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids
ISSN:
1388-1981
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Hepatic triacylglycerol levels are governed through synthesis, degradation and export of this lipid. Here we demonstrate that enforced expression of hepatic lipase in the endoplasmic reticulum in McArdle RH7777 hepatocytes resulted in a significant decrease in the incorporation of fatty acids into cellular triacylglycerol and cholesteryl ester accompanied by attenuation of secretion of apolipoprotein B-containing lipoproteins. Hepatic lipase-mediated depletion of intracellular lipid storage increased the expression of peroxisome proliferator-activated receptor α and its target genes and augmented oxidation of fatty acids. These data show that 1) hepatic lipase is active in the endoplasmic reticulum and 2) intracellular hepatic lipase modulates cellular lipid metabolism and lipoprotein secretion.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IFISE)
Articulos de INST.DE FISIOLOGIA EXPERIMENTAL (I)
Articulos de INST.DE FISIOLOGIA EXPERIMENTAL (I)
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Erickson, Bruce; Selvan, Senthamil Paramadayalan; Ko, Kerry W. S.; Kelly, Karen; Quiroga, Ariel Dario; et al.; Endoplasmic reticulum-localized hepatic lipase decreases triacylglycerol storage and VLDL secretion; Elsevier; Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids; 1831; 6; 6-2013; 1113-1123
Compartir
Altmétricas