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dc.contributor.author
Hughes, Michael F.
dc.contributor.author
Ross, David G.
dc.contributor.author
Starr, James M.
dc.contributor.author
Scollon, Edward J.
dc.contributor.author
Wolansky, Marcelo Javier
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dc.contributor.author
Crofton, Kevin M.
dc.contributor.author
DeVito, Michael J.
dc.date.available
2018-09-19T19:37:06Z
dc.date.issued
2016-06
dc.identifier.citation
Hughes, Michael F.; Ross, David G.; Starr, James M.; Scollon, Edward J.; Wolansky, Marcelo Javier; et al.; Environmentally relevant pyrethroid mixtures: A study on the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to motor activity in the rat; Elsevier Ireland; Toxicology; 359-360; 6-2016; 19-28
dc.identifier.issn
0300-483X
dc.identifier.uri
http://hdl.handle.net/11336/60320
dc.description.abstract
Human exposure to multiple pyrethroid insecticides may occur because of their broad use on crops and for residential pest control. To address the potential health risk from co-exposure to pyrethroids, it is important to understand their disposition and toxicity in target organs such as the brain, and surrogates such as the blood when administered as a mixture. The objective of this study was to assess the correlation between blood and brain concentrations of pyrethroids and neurobehavioral effects in the rat following an acute oral administration of the pyrethroids as a mixture. Male Long-Evans rats were administered a mixture of β-cyfluthrin, cypermethrin, deltamethrin, esfenvalerate and cis- and trans-permethrin in corn oil at seven dose levels. The pyrethroid with the highest percentage in the dosing solution was trans-permethrin (31% of total mixture dose) while deltamethrin and esfenvalerate had the lowest percentage (3%). Motor activity of the rats was then monitored for 1 h. At 3.5 h post-dosing, the animals were euthanized and blood and brain were collected. These tissues were extracted and analyzed for parent pyrethroid using HPLC-tandem mass spectrometry. Cypermethrin and cis-permethrin were the predominate pyrethroids detected in blood and brain, respectively, at all dosage levels. The relationship of total pyrethroid concentration between blood and brain was linear (r = 0.93). The pyrethroids with the lowest fraction in blood were trans-permethrin and β-cyfluthrin and in brain were deltamethrin and esfenvalerate. The relationship between motor activity of the treated rats and summed pyrethroid blood and brain concentration was described using a sigmoidal Emax model with the Effective Concentration50 being more sensitive for brain than blood. The data suggests summed pyrethroid rat blood concentration could be used as a surrogate for brain concentration as an aid to study the neurotoxic effects of pyrethroids administered as a mixture under the conditions used in this study.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dosimetry
dc.subject
Mixture
dc.subject
Neurotoxicity
dc.subject
Pesticide
dc.subject
Pyrethroid
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Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.subject.classification
Salud Ocupacional
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dc.subject.classification
Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Environmentally relevant pyrethroid mixtures: A study on the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to motor activity in the rat
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-30T15:10:55Z
dc.journal.volume
359-360
dc.journal.pagination
19-28
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Oxford
dc.description.fil
Fil: Hughes, Michael F.. National Health and Environmental Effects Research Laboratory; Estados Unidos
dc.description.fil
Fil: Ross, David G.. National Health and Environmental Effects Research Laboratory; Estados Unidos
dc.description.fil
Fil: Starr, James M.. National Exposure Research Laboratory; Estados Unidos
dc.description.fil
Fil: Scollon, Edward J.. National Health and Environmental Effects Research Laboratory; Estados Unidos
dc.description.fil
Fil: Wolansky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. National Research Council; Estados Unidos
dc.description.fil
Fil: Crofton, Kevin M.. National Health and Environmental Effects Research Laboratory; Estados Unidos
dc.description.fil
Fil: DeVito, Michael J.. National Health and Environmental Effects Research Laboratory; Estados Unidos
dc.journal.title
Toxicology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.tox.2016.06.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0300483X16301020?via%3Dihub
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