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dc.contributor.author
Lardizábal, María Noelia
dc.contributor.author
Rodriguez Virasoro, Ramiro Esteban
dc.contributor.author
Nocito, Ana Lía
dc.contributor.author
Daniele, Stella Maris
dc.contributor.author
Palatnik, Javier Fernando
dc.contributor.author
Veggi, Luis María
dc.date.available
2016-06-03T18:01:24Z
dc.date.issued
2014-01
dc.identifier.citation
Lardizábal, María Noelia; Rodriguez Virasoro, Ramiro Esteban; Nocito, Ana Lía; Daniele, Stella Maris; Palatnik, Javier Fernando; et al.; Alteration of the microRNA-122 regulatory network in rat models of hepatotoxicity; Elsevier Science; Environmental Toxicology and Pharmacology; 37; 1; 1-2014; 354-364
dc.identifier.issn
1382-6689
dc.identifier.uri
http://hdl.handle.net/11336/6030
dc.description.abstract
MicroRNAs are small RNA molecules that post-transcriptionally regulate gene expression. MicroRNA-122 is the most abundant and specific liver microRNA. Hepatotoxicity involves a significant alteration of liver gene expression. The aim of this work was to evaluate the microRNA-122 regulatory network in models of hepatotoxicity induced by thioacetamide or carbon tetrachloride. We report that the toxins decreased the expression of microRNA-122, which corresponded with an increase in two target genes: Cyclin G1 and the cationic amino acid transporter CAT-1. We found a decreased expression of its precursor, pri-microRNA-122, and of the transcription factors that specifically bind its promoter: CCAAT/enhancer-binding protein alpha, and members of the hepatocyte nuclear factor family. Therefore, microRNA-122 expression levels are under transcriptional control during hepatotoxicity. We propose that the changes observed are associated with the liver response to cope with the injury caused by the hepatotoxins, likely through a cell proliferation process to repair the damaged tissue.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Hepatotoxicity
dc.subject
Mir122
dc.subject
Microrna
dc.subject
Liver
dc.subject.classification
Toxicología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Alteration of the microRNA-122 regulatory network in rat models of hepatotoxicity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-01T14:03:45Z
dc.journal.volume
37
dc.journal.number
1
dc.journal.pagination
354-364
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Lardizábal, María Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet- Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.description.fil
Fil: Rodriguez Virasoro, Ramiro Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Nocito, Ana Lía. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina
dc.description.fil
Fil: Daniele, Stella Maris. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
dc.description.fil
Fil: Palatnik, Javier Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Veggi, Luis María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet- Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.journal.title
Environmental Toxicology and Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1382668913002809
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2013.12.008
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.etap.2013.12.008


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    Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO

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