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dc.contributor.author
Slater, Graham J.
dc.contributor.author
Cui, Pin
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Forasiepi, Analia Marta
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Lenz, Dorina
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Tsangaras, Kyriakos
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Voirin, Bryson
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De Moraes Barros, Nadia
dc.contributor.author
Greenwood, Alex D.
dc.date.available
2018-09-19T19:33:01Z
dc.date.issued
2016-02
dc.identifier.citation
Slater, Graham J.; Cui, Pin; Forasiepi, Analia Marta; Lenz, Dorina; Tsangaras, Kyriakos; et al.; Evolutionary relationships among extinct and extant sloths: The evidence of mitogenomes and retroviruses; Oxford University Press; Genome Biology and Evolution; 8; 3; 2-2016; 607-621
dc.identifier.issn
1759-6653
dc.identifier.uri
http://hdl.handle.net/11336/60298
dc.description.abstract
Macroevolutionary trends exhibited by retroviruses are complex and not entirely understood. The sloth endogenized foamy-like retrovirus (SloEFV), which demonstrates incongruence in virus-host evolution among extant sloths (Order Folivora), has not been investigated heretofore in any extinct sloth lineages and its premodern history within folivorans is therefore unknown. Determining retroviral coevolutionary trends requires a robust phylogeny of the viral host, but the highly reducedmodern sloth fauna (6 species in 2 genera) does not adequately represent whatwas once a highly diversified clade (∼100 genera) of placental mammals. At present, the amount of molecular data available for extinct sloth taxa is limited, and analytical results based on these data tend to conflict with phylogenetic inferences made on the basis of morphological studies. To augment themolecular data set, we applied hybridization capture and next-generation Illumina sequencing to two extinct and three extant sloth species to retrieve full mitochondrial genomes (mitogenomes) from the hosts and the polymerase gene of SloEFV. The results produced a fully resolved and well-supported phylogeny that supports dividing crown families into two major clades: 1) The three-toed sloth, Bradypus, and Nothrotheriidae and 2) Megalonychidae, including the two-toed sloth, Choloepus, and Mylodontidae. Our calibrated time tree indicates that the Miocene epoch (23.5 Ma), particularly its earlier part, was an important interval for folivoran diversification. Both extant and extinct sloths demonstrate multiple complex invasions of SloEFV into the ancestral sloth germline followed by subsequent introgressions across different sloth lineages. Thus, sloth mitogenome and SloEFV evolution occurred separately and in parallel among sloths.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ancient Dna
dc.subject
Foamy Virus
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Hybridization Capture
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Mitogenomes
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Retrovirus-Host Coevolution
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Sloth
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Evolutionary relationships among extinct and extant sloths: The evidence of mitogenomes and retroviruses
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-12T17:32:41Z
dc.journal.volume
8
dc.journal.number
3
dc.journal.pagination
607-621
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Slater, Graham J.. University of Chicago; Estados Unidos. National Museum of Natural History; Estados Unidos
dc.description.fil
Fil: Cui, Pin. Leibniz Institute for Zoo and Wildlife Research; Alemania
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Fil: Forasiepi, Analia Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentina
dc.description.fil
Fil: Lenz, Dorina. Leibniz Institute for Zoo and Wildlife Research; Alemania
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Fil: Tsangaras, Kyriakos. Leibniz Institute for Zoo and Wildlife Research; Alemania
dc.description.fil
Fil: Voirin, Bryson. Max Planck Institute For Ornithology; Alemania
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Fil: De Moraes Barros, Nadia. Universidad de Porto; Portugal
dc.description.fil
Fil: Greenwood, Alex D.. Leibniz Institute for Zoo and Wildlife Research; Alemania. Freie Universitat Berlin; Alemania
dc.journal.title
Genome Biology and Evolution
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1093/gbe/evw023
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/gbe/article/8/3/607/2574116
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