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dc.contributor.author Leonardi, Darío
dc.contributor.author Bombardiere, Maria Eugenia
dc.contributor.author Salomon, Claudio Javier
dc.date.available 2016-06-02T18:50:20Z
dc.date.issued 2013-10
dc.identifier.citation Leonardi, Darío; Bombardiere, Maria Eugenia; Salomon, Claudio Javier; Effects of benznidazole:cyclodextrin complexes on the drugbioavailability upon oral administration to rats; Elsevier; International Journal of Biological Macromolecules; 62; 10-2013; 543-548
dc.identifier.issn 0141-8130
dc.identifier.uri http://hdl.handle.net/11336/6021
dc.description.abstract Benznidazole (BZL) is the drug of choice for the treatment of Chagas´ s disease, a neglected parasitic infection. It is poorly soluble in water, which may have a direct impact into its bioavailability. Thus, the aim of this study was to evaluate the impact of stoichiometric and non-stoichiometric BZL:cyclodextrins (CDs) complexes on the bioavailability of BZL. The interaction of BZL with the CDs was investigated using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray diffractometry (XRD), phase solubility and dissolution studies. The oral bioavailability of BZL from these complexes was examined in rats. Both BZL solubility and dissolution increased by CD complexation. The inclusion complexes were found to improve the dissolution rate of BZL by 4.3-fold in comparison with BZL alone. Complexation of BZL with CDs derivatives increased its plasma concentrations when fed to rats, with AUC values increasing up to 3.7-fold and increasing 2.5-fold in comparison with BZL alone. It should be note that a remarkable increase in these parameters was observed in the case of the non-stoichiometric complexes. Thus, these CDs complexes could be used to efficiently deliver BZL in patients suffering from Chagas´ s disease.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject CHAGAS´ DISEASE
dc.subject COMPLEXATION
dc.subject CYCLODEXTRINS
dc.subject DISSOLUTION RATE
dc.subject.classification Otras Ciencias de la Salud
dc.subject.classification Ciencias de la Salud
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Effects of benznidazole:cyclodextrin complexes on the drugbioavailability upon oral administration to rats
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-06-01T13:35:11Z
dc.journal.volume 62
dc.journal.pagination 543-548
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
dc.description.fil Fil: Bombardiere, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
dc.description.fil Fil: Salomon, Claudio Javier. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
dc.journal.title International Journal of Biological Macromolecules
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0141813013005515
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ijbiomac.2013.10.007
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijbiomac.2013.10.007


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)