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dc.contributor.author
Marostica, Lucas Lourenço  
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de Barros, André Luís Branco  
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Oliveira, Juliana  
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Salgado, Breno Souza  
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Cassali, Geovanni Dantas  
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Leite, Elaine Amaral  
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Cardoso, Valbert Nascimento  
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Lang, Karen Luise  
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Caro, Miguel Soriano Balparda  
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Duran, Fernando Javier  
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Schenkel, Eloir Paulo  
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de Oliveira, Mônica Cristina  
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Simões, Cláudia Maria Oliveira  
dc.date.available
2018-09-18T19:46:54Z  
dc.date.issued
2017-08  
dc.identifier.citation
Marostica, Lucas Lourenço; de Barros, André Luís Branco; Oliveira, Juliana; Salgado, Breno Souza; Cassali, Geovanni Dantas; et al.; Antitumor effectiveness of a combined therapy with a new cucurbitacin B derivative and paclitaxel on a human lung cancer xenograft model; Academic Press Inc Elsevier Science; Toxicology and Applied Pharmacology; 329; 8-2017; 272-281  
dc.identifier.issn
0041-008X  
dc.identifier.uri
http://hdl.handle.net/11336/60133  
dc.description.abstract
Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors, with a high mortality rate due to the elevated risk of resistance. Natural cucurbitacins and their derivatives are recognized as promising antitumor compounds for several types of cancer, including NSCLC. In a recent study published by our research group, DACE (2-deoxy-2-amine-cucurbitacin E), which is a semisynthetic derivative of cucurbitacin B, showed potential in vitro synergistic antiproliferative effects combined with paclitaxel (PTX) in A549 cells. In sequence, the purpose of this study was to evaluate the in vivo antitumor efficacy of this combined therapy as well as with these drugs individually, using a human NSCLC xenograft model. Some indicators of sub chronic toxicity that could be affected by treatments were also assessed. The results obtained in vivo with the combined treatment (1 mg/kg + PTX 10 mg/kg) showed the most effective reduction of the relative tumor volume and the highest inhibition of tumor growth and proliferation, when compared with those of the single treatments. Furthermore, scintigraphic images, obtained before and after the treatments, showed that the most effective protocol able to reduce the residual viable tumor mass was the combined treatment. All treatment regimens were well tolerated without significant changes in body weight and no histological and functional damage to liver and kidney tissues. These results corroborate our previous in vitro synergistic effects published. Taken together, these insights are novel and highlight the therapeutic potential of DACE and PTX combination scheme for NSCLC.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Academic Press Inc Elsevier Science  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Antitumor Effect  
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Cucurbitacins  
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Lung Cancer  
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Paclitaxel  
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Scintigraphic Images  
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Xenograft Lung Tumor  
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Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Antitumor effectiveness of a combined therapy with a new cucurbitacin B derivative and paclitaxel on a human lung cancer xenograft model  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-09-04T19:01:51Z  
dc.journal.volume
329  
dc.journal.pagination
272-281  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Marostica, Lucas Lourenço. Universidade Federal de Santa Catarina; Brasil  
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Fil: de Barros, André Luís Branco. Universidade Federal de Minas Gerais; Brasil  
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Fil: Oliveira, Juliana. Universidade Federal de Minas Gerais; Brasil  
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Fil: Salgado, Breno Souza. Universidade Federal do Espírito Santo; Brasil  
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Fil: Cassali, Geovanni Dantas. Universidade Federal de Minas Gerais; Brasil  
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Fil: Leite, Elaine Amaral. Universidade Federal de Minas Gerais; Brasil  
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Fil: Cardoso, Valbert Nascimento. Universidade Federal de Minas Gerais; Brasil  
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Fil: Lang, Karen Luise. Universidade Federal de Santa Catarina; Brasil  
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Fil: Caro, Miguel Soriano Balparda. Universidade Federal de Santa Catarina; Brasil  
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Fil: Duran, Fernando Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina  
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Fil: Schenkel, Eloir Paulo. Universidade Federal de Santa Catarina; Brasil  
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Fil: de Oliveira, Mônica Cristina. Universidade Federal de Minas Gerais; Brasil  
dc.description.fil
Fil: Simões, Cláudia Maria Oliveira. Universidade Federal de Santa Catarina; Brasil  
dc.journal.title
Toxicology and Applied Pharmacology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.taap.2017.06.007  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0041008X17302636