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dc.contributor.author
Herrera, Fernando Enrique
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dc.contributor.author
Pantano Gutierrez, Sergio Fabian
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dc.date.available
2018-09-18T18:11:12Z
dc.date.issued
2012-01
dc.identifier.citation
Herrera, Fernando Enrique; Pantano Gutierrez, Sergio Fabian; Structure and dynamics of nano-sized raft-like domains on the plasma membrane; American Institute of Physics; Journal of Chemical Physics; 136; 1; 1-2012; 15103-15103
dc.identifier.issn
0021-9606
dc.identifier.uri
http://hdl.handle.net/11336/60102
dc.description.abstract
Cell membranes are constitutively composed of thousands of different lipidic species, whose specific organization leads to functional heterogeneities. In particular, sphingolipids, cholesterol and some proteins associate among them to form stable nanoscale domains involved in recognition, signaling, membrane trafficking, etc. Atomic-detail information in the nanometersecond scale is still elusive to experimental techniques. In this context, molecular simulations on membrane systems have provided useful insights contributing to bridge this gap. Here we present the results of a series of simulations of biomembranes representing non-raft and raft-like nano-sized domains in order to analyze the particular structural and dynamical properties of these domains. Our results indicate that the smallest (5 nm) raft domains are able to preserve their distinctive structural and dynamical features, such as an increased thickness, higher ordering, lower lateral diffusion, and specific lipid-ion interactions. The insertion of a transmembrane protein helix into non-raft, extended raft-like, and raft-like nanodomain environments result in markedly different protein orientations, highlighting the interplay between the lipid-lipid and lipid-protein interactions. © 2012 American Institute of Physics.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Institute of Physics
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Raft
dc.subject
Molecular Dynamics
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Structure and dynamics of nano-sized raft-like domains on the plasma membrane
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-18T16:24:04Z
dc.journal.volume
136
dc.journal.number
1
dc.journal.pagination
15103-15103
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Herrera, Fernando Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Institut Pasteur de Montevideo; Uruguay. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Física; Argentina
dc.description.fil
Fil: Pantano Gutierrez, Sergio Fabian. Institut Pasteur de Montevideo; Uruguay
dc.journal.title
Journal of Chemical Physics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1063/1.3672704
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://aip.scitation.org/doi/10.1063/1.3672704
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