Artículo
Synthesis, structure and SOD activity of Mn complexes with symmetric Schiff base ligands derived from pyridoxal
Signorella, Sandra Rosanna
; Daier, Veronica Andrea
; Ledesma, Gabriela Nanci
; Palopoli, Claudia Marcela
; Back, Davi Fernando; Lang, Ernesto S.; Rossini Kopp, Cristiéli; Ebani, Patrícia; Brum Pereira, Mateus; Giacomelli, Cristiano; Piquini, Paulo Cesar
Fecha de publicación:
09/2015
Editorial:
Elsevier
Revista:
Polyhedron
ISSN:
0277-5387
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This study describes the synthesis, crystal structure and antioxidant activity of manganese(III) complexes with Schiff-base ligands obtained from condensation of pyridoxal with alkyl diamines: [Mn(pyr2en) (H2O)2]Cl 4H2O, [Mn(pyr2en)(H2O)(CH3OH)]Cl, [Mn(pyr2pn)(H2O)2]ClO4 and [Mn2(pyr2bn)3] 4H2O, where H2pyr2en = 1,2-bis(pyridoxylidenamino)ethane, H2pyr2pn = 1,3-bis(pyridoxylidenamino)propane and H2pyr2bn = 1,4-bis(pyridoxylidenamino)butane. The four complexes catalyze the dismutation of superoxide efficiently with IC50 values in the range of 1.22?2.15 lM, evaluated through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The length of the alkyl spacer in the diamine fragment plays a key role in the antioxidant activity of these complexes, with [Mn(pyr2pn)(H2O)2]ClO4 showing the lowest IC50 value.
Palabras clave:
Pyridoxal Schiff Base
,
Complex Mn Chelates
,
Superoxide Activity
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Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Articulos de INST.DE QUIMICA ROSARIO
Citación
Signorella, Sandra Rosanna; Daier, Veronica Andrea; Ledesma, Gabriela Nanci; Palopoli, Claudia Marcela; Back, Davi Fernando; et al.; Synthesis, structure and SOD activity of Mn complexes with symmetric Schiff base ligands derived from pyridoxal; Elsevier; Polyhedron; 102; 9-2015; 176-184
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