Artículo
13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes
Ferreira, M. João G.; García, Agustina
; Leonardi, Darío
; Salomon, Claudio Javier
; Lamas, Maria Celina
; Nunes, T. G.
Fecha de publicación:
01/2015
Editorial:
Elsevier
Revista:
Carbohydrate Polymers
ISSN:
0144-8617
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
13C and 15N solid-state nuclear magnetic resonance (NMR) spectra were recorded from albendazole (ABZ) and from ABZ:β-cyclodextrin, ABZ:methyl-β-cyclodextrin, ABZ:hydroxypropyl-β-cyclodextrin and ABZ:citrate-β-cyclodextrin, which were prepared by the spray-drying technique. ABZ signals were typical of a crystalline solid for the pure drug and of an amorphous compound obtained from ABZ:cyclodextrin samples. Relevant spectral differences were correlated with chemical interaction between ABZ and cyclodextrins. The number and type of complexes revealed a strong dependence on the cyclodextrin group substituent. Solid-state NMR data were consistent with the presence of stable inclusion complexes.
Palabras clave:
Albendazole
,
Cyclodextrins
,
Solid State Nmr
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Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Articulos de INST.DE QUIMICA ROSARIO
Citación
Ferreira, M. João G.; García, Agustina; Leonardi, Darío; Salomon, Claudio Javier; Lamas, Maria Celina; et al.; 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes; Elsevier; Carbohydrate Polymers; 123; 1-2015; 130-135
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