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Artículo

Histological changes in lung tissues related with sub-chronic exposure to ambient urban levels of PM2.5 in Córdoba, Argentina

Tavera Busso, IvánIcon ; Vera, Anahi Griselda; Mateos, Ana CarolinaIcon ; Amarillo, Ana CarolinaIcon ; Carreras, Hebe AlejandraIcon
Fecha de publicación: 08/2017
Editorial: Pergamon-Elsevier Science Ltd
Revista: Atmospheric Environment
ISSN: 1352-2310
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Meteorología y Ciencias Atmosféricas

Resumen

Concentration of fine particulate matter (PM2.5) is one of the most important environmental parameters to estimate health impacts attributable to air pollution. Despite the fact there are many studies regarding PM2.5 effects on human health, most of them were performed under conditions that do not simulate the natural particles interaction with the organism. In the present paper, we studied the effects of mammals’ sub-chronic exposure to PM2.5 on the lower respiratory tract, addressing realistic exposure conditions to normal urban air. Thus, we exposed Wistar rats under controlled settings to the same normal urban air, with and without particles. Next, we analyzed chemical composition of PM2.5 and lungs samples, performed a histologic examination and run the comet assay to assess genotoxic effects. We found a strong agreement between lung tissues and PM2.5 elemental composition suggesting that metals found in lungs came from the particles inhaled. Histological analysis showed a mild to moderate infiltration, with a reduction of alveoli lumen and increment of alveolar macrophages and periodic acid-Schiff (PAS) (+) cells in treated animals. We also observed an increase in the number of nuclei with comets, mostly comets type 3, with a high DNA fragmentation as well. These results provide strong evidence that sub-chronic exposure to low particle levels, even below the 24 h WHO standard, can cause injuries in lungs tissues and DNA damage, as well.
Palabras clave: Comet Assay , Elemental Composition , Lung Histology , Pahs , Pm2.5
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/59868
URL: http://linkinghub.elsevier.com/retrieve/pii/S1352231017305745
DOI: https://doi.org/10.1016/j.atmosenv.2017.08.061
Colecciones
Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Citación
Tavera Busso, Iván; Vera, Anahi Griselda; Mateos, Ana Carolina; Amarillo, Ana Carolina; Carreras, Hebe Alejandra; Histological changes in lung tissues related with sub-chronic exposure to ambient urban levels of PM2.5 in Córdoba, Argentina; Pergamon-Elsevier Science Ltd; Atmospheric Environment; 167; 8-2017; 616-624
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