Artículo
Toward encoding reactivity using double-stranded DNA. Sequencedependent native chemical ligation of DNA binding polyamides
Fecha de publicación:
06/2013
Editorial:
Elsevier
Revista:
Tetrahedron
ISSN:
0040-4020
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The coupling reaction between distamycin-related polyamides equipped with cysteine and thioester groups can be accelerated in the presence of double-stranded (ds) oligonucleotides with selected sequences. While the coupling reaction of reactive partners containing three pyrrole units is accelerated by dsDNAs containing ATTTTA or ATGTTA sites, the heterodimeric coupling between a tripyrrole and a polyamide equipped with two pyrroles and one imidazole, is accelerated by the latter DNA, but not by the other containing the A/T rich tract. These differences can be exploited for selecting preferred coupling pairs from a mixture of reactive monomers; therefore the reaction outcome depends on the instructions provided by the dsDNA sequence.
Palabras clave:
Dna Binding
,
Native Chemical Ligation
,
Molecular Recognition
,
Polyamides
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Colecciones
Articulos(INQUISUR)
Articulos de INST.DE QUIMICA DEL SUR
Articulos de INST.DE QUIMICA DEL SUR
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Jimenez Balsa, Adrián ; Dodero, Veronica Isabel; Mascareñas, José L.; Toward encoding reactivity using double-stranded DNA. Sequencedependent native chemical ligation of DNA binding polyamides; Elsevier; Tetrahedron; 69; 36; 6-2013; 7847-7853
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