Artículo
Therapeutic blockade of Foxp3 in experimental breast cancer models
Moreno Ayala, Mariela Alejandra
; Gottardo, María Florencia
; Imsen, Mercedes
; Asad, Antonela Sofía
; Bal, Elisa Dora
; Casares, Noelia; Lasarte, Juan José; Seilicovich, Adriana
; Candolfi, Marianela
Fecha de publicación:
11/2017
Editorial:
Springer
Revista:
Breast Cancer Research and Treatment
ISSN:
0167-6806
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Purpose: Regulatory T cells (Tregs) impair the clinical benefit of cancer immunotherapy. To optimize the antitumor efficacy of therapeutic dendritic cell (DC) vaccines, we aimed to inhibit Foxp3, a transcription factor required for Treg function. Methods: Mice bearing established syngeneic LM3 and 4T1 breast tumors were treated with antitumor DC vaccines and a synthetic peptide (P60) that has been shown to inhibit Foxp3. Results: Treatment with P60 improved the therapeutic efficacy of DC vaccines in these experimental models. In addition, monotherapy with P60 inhibited tumor growth in immunocompetent as well as in immuno-compromised animals bearing established tumors. We found expression of Foxp3 in human and murine breast tumor cells. P60 inhibited IL-10 secretion in breast cancer cells that expressed Foxp3. Conclusions: Our results suggest that Foxp3 blockade improves the therapeutic efficacy of DC vaccines by inhibition of Tregs and through a direct antitumor effect. This strategy could prove useful to neutralize the immunosuppressive microenvironment and to boost antitumor immunity in breast cancer.
Palabras clave:
Breast Cancer
,
Dendritic Cell Vaccines
,
Foxp3
,
Immunotherapy
,
Regulatory T Cells
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Articulos(BIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos(INBIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Moreno Ayala, Mariela Alejandra; Gottardo, María Florencia; Imsen, Mercedes; Asad, Antonela Sofía; Bal, Elisa Dora; et al.; Therapeutic blockade of Foxp3 in experimental breast cancer models; Springer; Breast Cancer Research and Treatment; 166; 2; 11-2017; 393-405
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