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dc.contributor.author
Bezerra, Otávio C.
dc.contributor.author
França, Cristiane Miranda
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Rocha, Juraci Aparecida
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Neves, Gizele A.
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Souza, Pamella Ramona M.
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Teixeira Gomes, Mariana
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Malfitano, Christiane
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Loleiro, Tatiane C. Alba
dc.contributor.author
Dourado, Paulo Magno
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Llesuy, Susana Francisca
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dc.contributor.author
De Angelis, Katia
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Irigoyen, Maria Claudia C.
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Ulloa, Luis
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Consolim Colombo, Fernanda M.
dc.date.available
2018-09-12T18:18:20Z
dc.date.issued
2017-12
dc.identifier.citation
Bezerra, Otávio C.; França, Cristiane Miranda; Rocha, Juraci Aparecida; Neves, Gizele A.; Souza, Pamella Ramona M.; et al.; Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction; Nature Publishing Group; Scientific Reports; 7; 1; 12-2017; 1-12
dc.identifier.issn
0028-0836
dc.identifier.uri
http://hdl.handle.net/11336/59359
dc.description.abstract
We previously reported that cholinergic stimulation with pyridostigmine (PY) induces anti-inflammatory cell recruitment soon after myocardial infarction (MI). In this study, we evaluated the anti-inflammatory effects of PY during the proliferative phase of cardiac repair by analyzing the infiltration of macrophages, Treg lymphocytes, oxidative stress and inflammatory cytokines. Wistar rats underwent control sham surgery or ligation of the left coronary artery and were randomly allocated to remain untreated (untreated infarcted group, I) or to receive PY (30 mg·kg(-1)·day(-1)) in the supplied water (infarcted treated group, I + PY). Blood pressure and heart rate variability were registered at day 5 post-MI. The animals were euthanized 7 days after thoracotomy, when the hearts were removed and processed for immunohistochemistry (CD68, CD206, FOXP3), cytokines (IL-1β, IL-6, IL-10, TNF-α) and oxidative stress (superoxide dismutase, catalase, glutathione peroxidase, lipidic and protein peroxidation). PY treatment increased parasympathetic modulation, M2 macrophages and the anti-oxidant enzyme activity but reduced protein oxidation (carbonyls) and the concentration of IL-1β, IL-6, TNF-α and IL-10. Cholinergic stimulation induces parasympathetic neuro-immune modulation and anti-inflammatory cell enrollment as well as prevents oxidative stress and cytokine production after MI.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Estimulacion Colinergica
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Estres Oxidativo
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Infarto
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Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-11T14:49:36Z
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Bezerra, Otávio C.. Universidade Nove de Julho; Brasil
dc.description.fil
Fil: França, Cristiane Miranda. Universidade Nove de Julho; Brasil. Oregon Health and Science University; Estados Unidos
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Fil: Rocha, Juraci Aparecida. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Neves, Gizele A.. Universidade Nove de Julho; Brasil
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Fil: Souza, Pamella Ramona M.. Universidade Nove de Julho; Brasil
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Fil: Teixeira Gomes, Mariana. Universidade Nove de Julho; Brasil
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Fil: Malfitano, Christiane. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Loleiro, Tatiane C. Alba. Universidade de Sao Paulo; Brasil
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Fil: Dourado, Paulo Magno. Universidade de Sao Paulo; Brasil
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Fil: Llesuy, Susana Francisca. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: De Angelis, Katia. Universidade Nove de Julho; Brasil
dc.description.fil
Fil: Irigoyen, Maria Claudia C.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Ulloa, Luis. New Jersey Medical School; Estados Unidos
dc.description.fil
Fil: Consolim Colombo, Fernanda M.. Universidade Nove de Julho; Brasil. Universidade de Sao Paulo; Brasil
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-017-14021-8
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-14021-8
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