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dc.contributor.author Masson, Jesse J. R.
dc.contributor.author Murphy, Andrew J.
dc.contributor.author Lee, Man K. S.
dc.contributor.author Ostrowski, Matias
dc.contributor.author Crowe, Suzanne M.
dc.contributor.author Palmer, Clovis S.
dc.date.available 2018-09-11T18:19:46Z
dc.date.issued 2017-08
dc.identifier.citation Masson, Jesse J. R.; Murphy, Andrew J.; Lee, Man K. S.; Ostrowski, Matias; Crowe, Suzanne M.; et al.; Assessment of metabolic and mitochondrial dynamics in CD4+ and CD8+ T cells in virologically suppressed HIV-positive individuals on combination antiretroviral therapy; Public Library of Science; Plos One; 12; 8; 8-2017; 1-19; e0183931
dc.identifier.uri http://hdl.handle.net/11336/59139
dc.description.abstract Metabolism plays a fundamental role in supporting the growth, proliferation and effector functions of T cells. We investigated the impact of HIV infection on key processes that regulate glucose uptake and mitochondrial biogenesis in subpopulations of CD4+ and CD8+ T cells from 18 virologically-suppressed HIV-positive individuals on combination antiretroviral therapy (cART; median CD4+ cell count: 728 cells/μl) and 13 HIV seronegative controls. Mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) production were also analysed in total CD4+ and CD8+ T cells. Among HIV+/cART individuals, expression of glucose transporter (Glut1) and mitochondrial density were highest within central memory and naïve CD4+ T cells, and lowest among effector memory and transitional memory T cells, with similar trends in HIV-negative controls. Compared to HIV-negative controls, there was a trend towards higher percentage of circulating CD4+Glut1+ T cells in HIV+/cART participants. There were no significant differences in mitochondrial dynamics between subject groups. Glut1 expression was positively correlated with mitochondrial density and MMP in total CD4+ T cells, while MMP was also positively correlated with ROS production in both CD4+ and CD8+ T cells. Our study characterizes specific metabolic features of CD4+ and CD8+ T cells in HIV-negative and HIV+/cART individuals and will invite future studies to explore the immunometabolic consequences of HIV infection.
dc.format application/pdf
dc.language.iso eng
dc.publisher Public Library of Science
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Mitochondria
dc.subject HIV
dc.subject CD4+ T cell
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Assessment of metabolic and mitochondrial dynamics in CD4+ and CD8+ T cells in virologically suppressed HIV-positive individuals on combination antiretroviral therapy
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-09-11T14:49:22Z
dc.identifier.eissn 1932-6203
dc.journal.volume 12
dc.journal.number 8
dc.journal.pagination 1-19; e0183931
dc.journal.pais Estados Unidos
dc.journal.ciudad San Francisco
dc.description.fil Fil: Masson, Jesse J. R.. James Cook University; Australia. Burnet Institute; Australia
dc.description.fil Fil: Murphy, Andrew J.. Baker Heart and Diabetes Institute; Australia
dc.description.fil Fil: Lee, Man K. S.. Baker Heart and Diabetes Institute; Australia
dc.description.fil Fil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.description.fil Fil: Crowe, Suzanne M.. Burnet Institute; Australia. Monash University; Australia
dc.description.fil Fil: Palmer, Clovis S.. Burnet Institute; Australia. Monash University; Australia. University of Melbourne; Australia
dc.journal.title Plos One
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0183931
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183931
dc.conicet.fuente individual


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  • Articulos(INBIRS) [96]
    Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA

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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)