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dc.contributor.author
Ceci, Mónica  
dc.contributor.author
Delpech, Gastón  
dc.contributor.author
Sparo, Mónica Delfina  
dc.contributor.author
Mezzina, Vito  
dc.contributor.author
Sanchez Bruni, Sergio Fabian  
dc.contributor.author
Baldaccini, Maria Beatriz  
dc.date.available
2018-09-11T17:41:30Z  
dc.date.issued
2015-11  
dc.identifier.citation
Ceci, Mónica; Delpech, Gastón; Sparo, Mónica Delfina; Mezzina, Vito; Sanchez Bruni, Sergio Fabian; et al.; Clinical and microbiological features of bacteremia caused by enterococcus faecalis; JIDC; Journal of Infection in Developing Countries; 9; 11; 11-2015; 1195-1203  
dc.identifier.issn
2036-6590  
dc.identifier.uri
http://hdl.handle.net/11336/59108  
dc.description.abstract
Introduction: Enterococcus faecalis is a frequent etiologic agent of invasive infections in hospitalized patients. The aim of this study was to analyze clinical and microbiological features of bacteremia caused by E. faecalis. Methodology: Between 2011 and 2013, significant bacteremia caused by E. faecalis in hospitalized patients was studied. Patient characteristics, comorbid conditions, and 14-day mortality were recorded. Virulence genes esp, gelE, and cylA; opsonophagocytosis resistance; resistance to bactericidal effect of normal serum; beta lactamase production; and susceptibility to ampicillin, vancomycin, teicoplanin, gentamicin, and streptomycin were investigated. Results: E. faecalis strains were recovered from 33 bacteremic patients. Polymicrobial bacteremia was diagnosed in 2 patients; 10 patients died. Virulence genes were found in strains from both deceased patients and survivors. Sources of bacteremia included urinary tract infections (36.4%), vascular catheters (15.1%), abscesses (9.1%), and unknown (48.5%). Underlying diseases included cancer (30.3%), diabetes (36.4%), cirrhosis (6.1%), renal (36.4%), and chronic obstructive pulmonary disease (2.0%). Co-morbidities included alcohol use (26.1%); glucocorticoid therapy (19.0%); prior antibiotic therapy (60.6%); and central venous (21.2%), arterial (12.1%), and urinary (63.6%) catheters. Also, 57.6% of patients came from the intensive care unit (ICU); 33.3% had mechanical ventilation. Significant mortality-associated conditions included polymicrobial bacteremia, oncological disease, APACHE II score ≥ 20, ICU stay, renal disease, central venous catheter, and mechanical ventilation. Conclusions: Outcome of patients was associated with their status and not with the presence of virulence genes in E. faecalis strains. A significant percentage of bacteremia had undetermined origin. An alternate origin may be the gastrointestinal tract, through translocation.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
JIDC  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Bacteremia  
dc.subject
Co-Morbidity  
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E. Faecalis  
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Hospital  
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Mortality  
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Virulence Determinants  
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Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Clinical and microbiological features of bacteremia caused by enterococcus faecalis  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-09-05T15:53:28Z  
dc.identifier.eissn
1972-2680  
dc.journal.volume
9  
dc.journal.number
11  
dc.journal.pagination
1195-1203  
dc.journal.pais
Italia  
dc.description.fil
Fil: Ceci, Mónica. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina  
dc.description.fil
Fil: Delpech, Gastón. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Sparo, Mónica Delfina. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina  
dc.description.fil
Fil: Mezzina, Vito. Hospital Ramón Santamarina ; Argentina  
dc.description.fil
Fil: Sanchez Bruni, Sergio Fabian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Baldaccini, Maria Beatriz. Hospital Ramón Santamarina ; Argentina  
dc.journal.title
Journal of Infection in Developing Countries  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3855/jidc.6587  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://jidc.org/index.php/journal/article/view/26623628