Artículo
Alternative Conformations of Cytochrome c: Structure, Function, and Detection
Hannibal, Luciana; Tomasina, Florencia; Capdevila, Daiana Andrea
; Demicheli, Verónica; Tórtora, Verónica; Álvarez Paggi, Damián Jorge
; Jemmerson, Ronald; Murgida, Daniel Horacio
; Radi, Rafael
Fecha de publicación:
01/2016
Editorial:
American Chemical Society
Revista:
Biochemistry
ISSN:
0006-2960
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Cytochrome c (cyt c) is a cationic hemoprotein of ∼100 amino acid residues that exhibits exceptional functional versatility. While its primary function is electron transfer in the respiratory chain, cyt c is also recognized as a key component of the intrinsic apoptotic pathway, the mitochondrial oxidative protein folding machinery, and presumably as a redox sensor in the cytosol, along with other reported functions. Transition to alternative conformations and gain-of-peroxidase activity are thought to further enable the multiple functions of cyt c and its translocation across cellular compartments. In vitro, direct interactions of cyt c with cardiolipin, post-translational modifications such as tyrosine nitration, phosphorylation, methionine sulfoxidation, mutations, and even fine changes in electrical fields lead to a variety of conformational states that may be of biological relevance. The identification of these alternative conformations and the elucidation of their functions in vivo continue to be a major challenge. Here, we unify the knowledge of the structural flexibility of cyt c that supports functional moonlighting and review biochemical and immunochemical evidence confirming that cyt c undergoes conformational changes during normal and altered cellular homeostasis.
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Articulos(INQUIMAE)
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Citación
Hannibal, Luciana; Tomasina, Florencia; Capdevila, Daiana Andrea; Demicheli, Verónica; Tórtora, Verónica; et al.; Alternative Conformations of Cytochrome c: Structure, Function, and Detection; American Chemical Society; Biochemistry; 55; 3; 1-2016; 407-428
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