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dc.contributor.author
Kanmani, Paulraj
dc.contributor.author
Albarracín, Leonardo Miguel
dc.contributor.author
Kobayashi, Hisakazu
dc.contributor.author
Iida, Hikaru
dc.contributor.author
Komatsu, Ryoya
dc.contributor.author
Kober, Humayun A. K. M.
dc.contributor.author
Ikeda-Ohtsubo, Wakako
dc.contributor.author
Suda, Yoshihito
dc.contributor.author
Aso, Hisashi
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Makino, Seiya
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Kano, Hiroshi
dc.contributor.author
Saito, Tadao
dc.contributor.author
Villena, Julio Cesar
dc.contributor.author
Kitazawa, Haruki
dc.date.available
2018-09-10T21:04:11Z
dc.date.issued
2018-01
dc.identifier.citation
Kanmani, Paulraj; Albarracín, Leonardo Miguel; Kobayashi, Hisakazu; Iida, Hikaru; Komatsu, Ryoya; et al.; Exopolysaccharides from Lactobacillus delbrueckii OLL1073R-1 modulate innate antiviral immune response in porcine intestinal epithelial cells; Pergamon-Elsevier Science Ltd; Molecular Immunology; 93; 1-2018; 253-265
dc.identifier.issn
0161-5890
dc.identifier.uri
http://hdl.handle.net/11336/58988
dc.description.abstract
Previous studies demonstrated that the extracellular polysaccharides (EPSs) produced by Lactobacillus delbrueckii OLL1073R-1 (LDR-1) improve antiviral immunity, especially in the systemic and respiratory compartments. However, it was not studied before whether those EPSs are able to beneficially modulate intestinal antiviral immunity. In addition, LDR-1-host interaction has been evaluated mainly with immune cells while its interaction with intestinal epithelial cells (IECs) was not addressed before. In this work, we investigated the capacity of EPSs from LDR-1 to modulate the response of porcine IECs (PIE cells) to the stimulation with the Toll-like receptor (TLR)-3 agonist poly(I:C) and the role of TLR2, TLR4, and TLR negative regulators in the immunoregulatory effect. We showed that innate immune response triggered by TLR3 activation in porcine IECs was differentially modulated by EPS from LDR-1. EPSs treatment induced an increment in the expression of interferon (IFN)-α and IFN-β in PIE cells after the stimulation with poly(I:C) as well as the expression of the antiviral factors MxA and RNase L. Those effects were related to the reduced expression of A20 in EPS-treated PIE cells. EPS from LDR-1 was also able to reduce the expression of IL-6 and proinflammatory chemokines. Although further in vivo studies are needed, our results suggest that these EPSs or a yogurt fermented with LDR-1 have potential to improve intestinal innate antiviral response and protect against intestinal viruses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Anti-Inflammatory Activity
dc.subject
Antiviral Activity
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Exopolysaccharides
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Immune Modulation
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Porcine Intestinal Epithelial Cells
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Probiotics
dc.subject.classification
Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Exopolysaccharides from Lactobacillus delbrueckii OLL1073R-1 modulate innate antiviral immune response in porcine intestinal epithelial cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-26T18:15:56Z
dc.identifier.eissn
1872-9142
dc.journal.volume
93
dc.journal.pagination
253-265
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Kanmani, Paulraj. Tohoku University; Japón
dc.description.fil
Fil: Albarracín, Leonardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón
dc.description.fil
Fil: Kobayashi, Hisakazu. Tohoku University; Japón
dc.description.fil
Fil: Iida, Hikaru. Tohoku University; Japón
dc.description.fil
Fil: Komatsu, Ryoya. Tohoku University; Japón
dc.description.fil
Fil: Kober, Humayun A. K. M.. Tohoku University; Japón. Chittagong Veterinary and Animal Sciences University. Department of Dairy & Poultry Science; Bangladesh
dc.description.fil
Fil: Ikeda-Ohtsubo, Wakako. Tohoku University; Japón
dc.description.fil
Fil: Suda, Yoshihito. Miyagi University. Department of Food, Agriculture and Environment; Japón
dc.description.fil
Fil: Aso, Hisashi. Tohoku University; Japón
dc.description.fil
Fil: Makino, Seiya. Meiji Co., Ltd. Food Science Research Laboratory; Japón
dc.description.fil
Fil: Kano, Hiroshi. Meiji Co., Ltd. Food Science Research Laboratory; Japón
dc.description.fil
Fil: Saito, Tadao. Tohoku University; Japón
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón
dc.description.fil
Fil: Kitazawa, Haruki. Tohoku University; Japón
dc.journal.title
Molecular Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.molimm.2017.07.009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S016158901730439X
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