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dc.contributor.author
Silva, Clara del Valle
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dc.contributor.author
Nader, Maria Elena Fatima
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dc.date.available
2018-09-10T19:15:15Z
dc.date.issued
2006-12
dc.identifier.citation
Silva, Clara del Valle; Nader, Maria Elena Fatima; Norfloxacin treatment on E. coli in the urinary tract of mice: Effect of probiotic Lactobacilli; Medwell online; International Journal of Molecular Medicine and Advances Sciences; 2; 4; 12-2006; 360-365
dc.identifier.issn
1813-176x
dc.identifier.uri
http://hdl.handle.net/11336/58961
dc.description.abstract
This study was perfomed to evaluate the effect of the treatment of norfloxacin, as an antimicrobial agent, on the uropathogenic Escherichia coli colonization in mice, complemented by Lactobacilli as probiotics. Norfloxacin (5.5 mg. Kg-1 dose) was administred orally before and after the challenge with E. coli. The animals were also inoculated intra-urethrally with agarose beads containing L. fermentum. The population of the microorganisms in the urogenital tract was measured various days throughout the study. Using either 1 or 3 doses of norfloxacion befor or after the animal had been challenged with E. coli bacteria, reduced the E. coli population the urinary tract. The Norfloxacin treatment after the animals were administered 1 or 3 doses of agarose beads of lactobacilli significantly affected the viability of the lactic acid bacteria in all of the urinary tract organs and the number of E. coly (regardless to when the antibiotic was inoculated) was lower in the mice treated with lactobacilli than in the non-lactobacilli treated mice. Eventhough the survival of the lactobacilli was highly affected by the norfloxacin treatment, the uropathogenic E. coli colonization always decreased more than the lactobacilli population did and often completely disappeared in those animals which were treated with both norfloxacin and probiotic lactobacilli. Through this experimental model one can conclude that lactobacilli increases the effectiveness of the norfloxacin medication in the prevention and treatment of UTI produced by E. coli. Further studies are being performed to determine the mechanisms involved in this probiotic effect.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Medwell online
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Probiotics
dc.subject
Norfloxacin
dc.subject
Urinary Tract Infections
dc.subject
Prevention
dc.subject
E. Coli
dc.subject
L. Fermentum
dc.subject
Recurrence
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Norfloxacin treatment on E. coli in the urinary tract of mice: Effect of probiotic Lactobacilli
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-13T18:14:07Z
dc.identifier.eissn
1994-4624
dc.journal.volume
2
dc.journal.number
4
dc.journal.pagination
360-365
dc.journal.pais
India
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dc.journal.ciudad
Bangalore
dc.description.fil
Fil: Silva, Clara del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Nader, Maria Elena Fatima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.journal.title
International Journal of Molecular Medicine and Advances Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.medwelljournals.com/archive.php?jid=1813-176x
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