Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

The HNO donor ability of hydroxamic acids upon oxidation with cyanoferrates(III)

Gutierrez, Maria Marta; Almaraz, Alejandra E.; Bari, Sara ElizabethIcon ; Olabe Iparraguirre, Jose AntonioIcon ; Amorebieta, Valentín TomásIcon
Fecha de publicación: 09/2015
Editorial: Taylor & Francis Ltd
Revista: Journal of Coordination Chemistry
ISSN: 0095-8972
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Químicas

Resumen

The hydroxamic acids (RC(O)NHOH, HA) exhibit diverse biological activity, including hypotensive properties associated with formation of nitroxyl (HNO) or nitric oxide (NO). Oxidation of two HAs, benzohydroxamic and acetohydroxamic acids (BHA, AHA) by [Fe(CN)5NH3]2- or [Fe(CN)6]3- was analyzed by spectroscopic, mass spectrometric techniques, and flow EPR measurements. Mixing BHA with both Fe(III) reactants at pH 11 allowed detecting the hydroxamate radical, (C6H5)C(O)NO-, as a one-electron oxidation product, as well as N2O as a final product. Successive UV-vis spectra of mixtures containing [Fe(CN)5NH3]2- (though not [Fe(CN)6]3-) at pH 11 and 7 revealed an intermediate acylnitroso-complex, [Fe(CN)5NOC(O)(C6H5)]3- (max, 465 nm, very stable at pH 7), formed through ligand interchange in the initially formed reduction product, [Fe(CN)5NH3]3-, and characterized by FTIR spectra through the stretching vibrations (CN), (CO), and (NO). Free acylnitroso derivatives, formed by alternative reaction paths of the hydroxamate radicals, hydrolyze forming RC(O)OH and HNO, postulated as precursor of N2O. Minor quantities of NO are formed only with an excess of oxidant. The intermediacy of HNO was confirmed through its identification as [Fe(CN)5(HNO)]3- (max, 445 nm) as a result of hydrolysis of [Fe(CN)5(NOC(O)(C6H5)]3- at pH 11. The results demonstrate that hydroxamic acids behave predominantly as HNO donors.
Palabras clave: Acylnitroso Species , Hydroxamic Acids , Nitroxyl , Nitroxyl Donor , Pentacyano(L)Ferrate(Iii) Oxidants
Ver el registro completo
 
Archivos asociados
Thumbnail
 
Tamaño: 894.8Kb
Formato: PDF
.
Descargar
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/58880
DOI: https://dx.doi.org/10.1080/00958972.2015.1068938
URL: https://www.tandfonline.com/doi/full/10.1080/00958972.2015.1068938
Colecciones
Articulos(INQUIMAE)
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Citación
Gutierrez, Maria Marta; Almaraz, Alejandra E.; Bari, Sara Elizabeth; Olabe Iparraguirre, Jose Antonio; Amorebieta, Valentín Tomás; The HNO donor ability of hydroxamic acids upon oxidation with cyanoferrates(III); Taylor & Francis Ltd; Journal of Coordination Chemistry; 68; 17-18; 9-2015; 3236-3246
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES