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dc.contributor.author
Mendizabal, Manuel
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Haddad, Leila
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Gallardo, Patricia E.
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Ferrada, Alejandro
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Soza, Alejandro A.
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Adrover, Raul
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Aravena, Edmundo
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Roblero, Juan P.
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Prieto, Jhon
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Vujacich, Claudia
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Romero, Gustavo
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Muñoz, Alberto
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Anders, Margarita
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Hernández, Nelia
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Coccozella, Daniel
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Gruz, Fernando
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Reggiardo, Maria V.
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Ruf, Andres E.
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Varón, Adriana
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Cartier, Mariano
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Pérez Ravier, Roberto
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Ridruejo, Ezequiel
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Peralta, Mirta
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Poncino, Daniel
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Vorobioff, Julio
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Aballay Soteras, Gabriel
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Silva, Marcelo O.
dc.date.available
2018-09-07T19:53:11Z
dc.date.issued
2017-09
dc.identifier.citation
Mendizabal, Manuel; Haddad, Leila; Gallardo, Patricia E.; Ferrada, Alejandro; Soza, Alejandro A.; et al.; Ombitasvir/paritaprevir/ritonavir/dasabuvir ± ribavirin is safe and effective in HCV-infected patients in a real-life cohort from Latin America; Wiley-liss, Div John Wiley & Sons Inc; Journal of Medical Virology; 89; 9; 9-2017; 1590-1596
dc.identifier.issn
0146-6615
dc.identifier.uri
http://hdl.handle.net/11336/58834
dc.description.abstract
Information about the use of ombitasvir/paritaprevir/ritonavir/dasabuvir ± ribavirin (OBV/PTV/r/DSV ± RBV) in real-clinical practice in Latin America is scarce. We aimed to confirm safety and effectiveness of OBV/PTV/r/DSV ± RBV therapy in real-world setting. We analyzed a cohort of patients with genotype 1 infection treated with OBV/PTV/r/DSV ± RBV. Data on demographics, clinical features, safety, and virological response were retrospectively collected from 21 centers in Latin America. A total of 96 patients received OBV/PTV/r/DSV, associated with RBV in 68% of the cases. Most were genotype 1b (80%), 56 (58%) had cirrhosis, and 45 (47%) failed prior HCV treatment. Adverse events occurred in 62% of patients. The most common adverse events were pruritus (21%), hyperbilirubinemia (17%), and asthenia (17%). Five patients discontinued therapy prematurely due to hepatic decompensation, three of them were Child-Pugh B at baseline and one patient died due to multi-organ failure. Follow up HCV-RNA 12 weeks after completion of therapy was evaluated in all the patients and sustained virologic response rate was 97%. No virologic breakthrough was detected. Our study confirms that OBV/PTV/r/DSV treatment is highly effective in patients with chronic HCV without cirrhosis or with Child-Pugh A cirrhosis in non-European populations. Adverse events were often mild and rarely led to treatment discontinuation except for patients with Child-Pugh B cirrhosis or with previous history of hepatic decompensation. These results can support the development of public strategies to expand the access of OBV/PTV/r + DSV and other DAAs combinations in order to reduce the burden of HCV infection in our region.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antiviral Agents
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Disease Control
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Hepatitis C Virus
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Public Policy
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Ombitasvir/paritaprevir/ritonavir/dasabuvir ± ribavirin is safe and effective in HCV-infected patients in a real-life cohort from Latin America
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-27T17:59:32Z
dc.journal.volume
89
dc.journal.number
9
dc.journal.pagination
1590-1596
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Mendizabal, Manuel. Hospital Universitario Austral; Argentina
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Fil: Haddad, Leila. Hospital Italiano; Argentina
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Fil: Gallardo, Patricia E.. Fundación Sayani; Argentina
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Fil: Ferrada, Alejandro. Hospital Clinico San Borja Arriaran; Chile
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Fil: Soza, Alejandro A.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
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Fil: Adrover, Raul. Centro de Hepatología; Argentina
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Fil: Aravena, Edmundo. Hospital Clinico San Borja Arriaran; Chile
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Fil: Roblero, Juan P.. Hospital Clinico San Borja Arriaran; Chile
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Fil: Prieto, Jhon. Clínica Universitaria Colombia y Centro de Enfermedades Hepáticas y Digestivas; Colombia
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Fil: Vujacich, Claudia. Fundacion Centro de Estudios Infectologicos; Argentina
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Fil: Romero, Gustavo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; Argentina
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Fil: Muñoz, Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; Argentina
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Fil: Anders, Margarita. Hospital Alemán; Argentina
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Fil: Hernández, Nelia. Hospital de Clinicas Dr. Manuel Quintela; Uruguay
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Fil: Coccozella, Daniel. Centro de Hepatología; Argentina
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Fil: Gruz, Fernando. Fundación Favaloro; Argentina
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Fil: Reggiardo, Maria V.. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
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Fil: Ruf, Andres E.. FUNDIEH; Argentina
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Fil: Varón, Adriana. Instituto de Cardiologia; Colombia
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Fil: Cartier, Mariano. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; Argentina
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Fil: Pérez Ravier, Roberto. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
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Fil: Ridruejo, Ezequiel. Hospital Universitario Austral; Argentina. Centro de Educación Medica E Invest.clinicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Peralta, Mirta. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas ; Argentina
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Fil: Poncino, Daniel. Sanatorio Municipal Dr. Julio Méndez; Argentina
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Fil: Vorobioff, Julio. Universidad Nacional de Rosario; Argentina
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Fil: Aballay Soteras, Gabriel. Sanatorio Mitre; Argentina
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Fil: Silva, Marcelo O.. Hospital Universitario Austral; Argentina
dc.journal.title
Journal of Medical Virology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/28370222
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info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/jmv.24816
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info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.24816
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