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dc.contributor.author
Fernandez, Vanesa
dc.contributor.author
Cadenazzi, Gabriela
dc.contributor.author
Miranda Miranda, E.
dc.contributor.author
Larsen, Karen Elizabeth
dc.contributor.author
Solana, Hugo Daniel
dc.date.available
2018-09-06T18:16:42Z
dc.date.issued
2015-10
dc.identifier.citation
Fernandez, Vanesa; Cadenazzi, Gabriela; Miranda Miranda, E.; Larsen, Karen Elizabeth; Solana, Hugo Daniel; A Multienzyme Response is involved in the Phenomenon of Fasciola hepatica Resistance to Triclabendazole; OMICS; Journal of Drug Metabolism and Toxicology; 6; 4; 10-2015; 1-4
dc.identifier.issn
2157-7609
dc.identifier.uri
http://hdl.handle.net/11336/58561
dc.description.abstract
The trematode Fasciola hepatica is the causative agent of a parasitic zoonosis known as fasciolosis, disease that affects humans and most species of domestic animals. Triclabendazole (TCBZ) is the most widely used fasciolicide,however, its indiscriminate use has led to the expression of anthelmintic resistance in the liver fluke.In the present work we evaluated ?in vitro? the microsomes activity of different xenobiotic metabolizing enzymes of Phase I Carboxylesterases (CE) and Phase II the cytosolic activity of Glutathione S-Transferase (GST),Glutathione peroxidase (GPx) and Glutathione Reductase (GSR) in adults of F. hepatica susceptible (Cullompton strain) and resistant (Sligo and Oberon strains) to triclabendazole. In this work is detected a multienzyme response involving at all the family of enzymes glutathione dependent. Carboxylesterases activity did not differ between the different strains tested not being involved in the resistance phenomenon. These results contribute to the understanding of the mechanisms referred to the phenomenon of resistance to TCBZ.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
OMICS
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Fasciola Hepatica
dc.subject
Resistencia
dc.subject
Triclabendazol
dc.subject
Enzimas
dc.subject.classification
Ciencias Veterinarias
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Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
A Multienzyme Response is involved in the Phenomenon of Fasciola hepatica Resistance to Triclabendazole
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-05T15:51:05Z
dc.journal.volume
6
dc.journal.number
4
dc.journal.pagination
1-4
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Fernandez, Vanesa. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Cadenazzi, Gabriela. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.description.fil
Fil: Miranda Miranda, E.. Centro Nacional de Investigación Disciplinaria en Parasitología; México
dc.description.fil
Fil: Larsen, Karen Elizabeth. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Solana, Hugo Daniel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Laboratorio de Biología Celular y Molecular; Argentina
dc.journal.title
Journal of Drug Metabolism and Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4172/2157-7609.1000192
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/a-multienzyme-response-is-involved-in-the-phenomenon-of-fasciola-hepaticaresistance-to-triclabendazole-2157-7609-1000192.php?aid=62728


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