Artículo
The herbicide glyphosate is a weak inhibitor of acetylcholinesterase in rats
Fecha de publicación:
07/2016
Editorial:
Elsevier Science
Revista:
Environmental Toxicology and Pharmacology
ISSN:
1382-6689
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The current work evaluated the inhibitory potency of the herbicide glyphosate (GLP) on acetylcholinesterase (AChE) activity in male and female rat tissues. The AChE activity in brain was higher (p < 0.05) than those observed in kidney (females: 2.2-fold; males: 1.9-fold), liver (females: 6-fold; males: 6.9-fold) and plasma (females: 14.7-fold; males: 25.3-fold). Enzyme activities were higher in presence of 10 mM GLP compared to those measured at an equimolar concentration of the potent AChE inhibitor dichlorvos (DDVP). Moreover, IC50s for GLP resulted between 6 × 104- and 6.8 × 105-fold higher than those observed for DDVP. In conclusion, GLP is a weak inhibitor of AChE in rats.
Palabras clave:
Acetylcholinesterase
,
Dichlorvos
,
Glyphosate
,
Rats
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683.5Kb
Formato:
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Licencia
Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción:
Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
Colecciones
Articulos(CCT - TANDIL)
Articulos de CTRO CIENTIFICO TECNOLOGICO CONICET - TANDIL
Articulos de CTRO CIENTIFICO TECNOLOGICO CONICET - TANDIL
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Larsen, Karen Elizabeth; Lifschitz, Adrian Luis; Lanusse, Carlos Edmundo; Virkel, Guillermo Leon; The herbicide glyphosate is a weak inhibitor of acetylcholinesterase in rats; Elsevier Science; Environmental Toxicology and Pharmacology; 45; 7-2016; 41-44
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