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Artículo

The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii

Lozano, Esteban SebastiánIcon ; Strauss, MarianaIcon ; Spina Zapata, Renata MaríaIcon ; Cifuente, Diego AlbertoIcon ; Tonn, Carlos EugenioIcon ; Rivarola, Hector Walter; Sosa Escudero, Miguel AngelIcon
Fecha de publicación: 02/02/2016
Editorial: Elsevier Ireland
Revista: Parasitology International
ISSN: 1383-5769
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Parasitología

Resumen

The search for new compounds with trypanocidal activity is crucial for the treatment of Chagas' disease. Previous in vitro studies have shown that the diterpene 5-epi-icetexone (ICTX) is active against Trypanosoma cruzi. The aim of this work was to evaluate the effect of ICTX on the parasites in infected mice, in an experimental model that mimics the acute phase of the disease. Swiss albino mice were infected with T. cruzi and treated daily with 10 mg/kg/day ICTX (i.p.). Infected mice and mice injected with either saline or the vehicle DMSO were used as controls. Animals' survival and parasitemia were monitored once a week and histological studies were made at necropsy by the 5th week after infection. It was observed that the administration of ICTX increased the survival of mice infected, and induced a significant decrease in the parasitemia, as compared to controls. A similar protective effect was observed when animals were treated orally with benznidazole (BZN, used as a control of antiparasitic effect). By the 5th week post-infection, the presence of amastigote nests was observed within the fibers of the cardiac and skeletal muscle in controls, but not in animals treated with either ICTX or BZN. In addition, inflammatory infiltrates were observed in the tissues of controls, but not in animals treated with the drugs. We conclude that ICTX has an antiparasitic effect against T. cruzi, thus constituting an interesting option for the treatment of Chagas' disease, alone or combined with other drugs.
Palabras clave: CHAGAS' DISEASE , DITERPENES , NATURAL COMPOUNDS , TRYPANOSOMA CRUZI
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/5818
URL: http://www.sciencedirect.com/science/article/pii/S1383576915001439
DOI: http://dx.doi.org/10.1016/j.parint.2015.08.011
Colecciones
Articulos(IHEM)
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Articulos(INTEQUI)
Articulos de INST. DE INVEST. EN TECNOLOGIA QUIMICA
Citación
Lozano, Esteban Sebastián; Strauss, Mariana; Spina Zapata, Renata María; Cifuente, Diego Alberto; Tonn, Carlos Eugenio; et al.; The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii; Elsevier Ireland; Parasitology International; 65; 1; 2-2-2016; 23-26
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