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Artículo

O-(β-hydroxyethyl)rutosides determination by micellar flow injection (FI) spectrofluorimetry

Fernandez, Liliana PatriciaIcon ; Peralta, Cecilia MarianaIcon
Fecha de publicación: 07/2014
Editorial: Elsevier
Revista: Journal of Pharmaceutical Analysis
ISSN: 2095-1779
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Analítica

Resumen

A simple, eco friendly, sensitive and economic flow injection spectrofluorimetric method was developed for the determination of O-(β-hydroxyethyl)rutosides. The procedure was based on the use of an anionic surfactant such as sodium dodecyl sulfate to provide an appreciable O-(β- hydroxyethyl)rutosides fluorescence enhancement, increasing considerably the sensitivity of detection. All the variables affecting the fluorescence intensity were studied and optimized. The flow rate was 5 mL/min with detection at 450 nm (after excitation at 346 nm). A linear correlation between drug amount and peak area was established for O-(β-hydroxyethyl)rutosides in the range of 0.01 - 200 μg/mL with a detection limit of 0.001 μg/mL (s/n = 3). Validation processes were performed by recovering studies with satisfactory results. The new methodology can be employed for the routine analysis of O-(β-hydroxyethyl)rutosides in bulks as well as in commercial formulations.
Palabras clave: O-(Β-Hydroxyethyl)Rutosides , Micellar Enhancement , Flow Injection , Spectrofluorimetry , Pharmaceuticals
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/5766
URL: http://www.sciencedirect.com/science/article/pii/S2095177914000628
DOI: http://dx.doi.org/ 10.1016/j.jpha.2014.07.002
DOI: http://dx.doi.org/10.1016/j.jpha.2014.07.002
Colecciones
Articulos(CCT - SAN LUIS)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SAN LUIS
Articulos(INQUISAL)
Articulos de INST. DE QUIMICA DE SAN LUIS
Citación
Fernandez, Liliana Patricia; Peralta, Cecilia Mariana; O-(β-hydroxyethyl)rutosides determination by micellar flow injection (FI) spectrofluorimetry; Elsevier; Journal of Pharmaceutical Analysis; 4; 6; 7-2014; 368-373
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