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dc.contributor.author
Sun, Fei
dc.contributor.author
Bahat, Anat
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Gakamsky, Anna
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Girsh, Eliezer
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Katz, Nathan
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Giojalas, Laura Cecilia
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Tur-Kaspa, Ilan
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Eisenbach, Michael
dc.date.available
2018-08-29T20:01:18Z
dc.date.issued
2005-03
dc.identifier.citation
Sun, Fei; Bahat, Anat; Gakamsky, Anna; Girsh, Eliezer; Katz, Nathan; et al.; Human sperm chemotaxis: Both the oocyte and its surrounding cumulus cells secrete sperm chemoattractants; Oxford University Press; Human Reproduction; 20; 3; 3-2005; 761-767
dc.identifier.issn
0268-1161
dc.identifier.uri
http://hdl.handle.net/11336/57580
dc.description.abstract
Background: Human sperm chemotaxis to pre-ovulatory follicular fluid is well established in vitro. However, it is not known whether the female's oocyte-cumulus complex secretes sperm chemoattractants subsequent to ovulation (for enabling sperm chemotaxis within the Fallopian tube) and, if so, which of these cell types - the oocyte or the cumulus oophorus - is the physiological origin of the secreted chemoattractant. Methods: By employing a directionality-based chemotaxis assay, we examined whether media conditioned with either individual, mature (metaphase II) human oocytes or the surrounding cumulus cells attract human sperm by chemotaxis. Results: We observed sperm chemotaxis to each of these media, suggesting that both the oocyte and the cumulus cells secrete sperm chemoattractants. Conclusions: These observations suggest that sperm chemoattractants are secreted not only prior to ovulation within the follicle, as earlier studies have demonstrated, but also after oocyte maturation outside the follicle, and that there are two chemoattractant origins: the mature oocyte and the surrounding cumulus cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Chemotaxis
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Cumulus Cells
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Oocyte-Conditioned Medium
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Ovum
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Sperm Chemoattractant
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Human sperm chemotaxis: Both the oocyte and its surrounding cumulus cells secrete sperm chemoattractants
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-13T17:05:23Z
dc.identifier.eissn
1460-2350
dc.journal.volume
20
dc.journal.number
3
dc.journal.pagination
761-767
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Sun, Fei. Weizmann Institute of Science. Department of Biological Chemistry; Israel
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Fil: Bahat, Anat. Weizmann Institute of Science. Department of Biological Chemistry; Israel
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Fil: Gakamsky, Anna. Weizmann Institute of Science. Department of Biological Chemistry; Israel
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Fil: Girsh, Eliezer. Ben Gurion University of the Negev; Israel
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Fil: Katz, Nathan. Ben Gurion University of the Negev; Israel
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Fil: Giojalas, Laura Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
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Fil: Tur-Kaspa, Ilan. Ben Gurion University of the Negev; Israel
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Fil: Eisenbach, Michael. Weizmann Institute of Science. Department of Biological Chemistry; Israel
dc.journal.title
Human Reproduction
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/humrep/article/20/3/761/2356534
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/humrep/deh657
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