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Artículo

Electrostatic interactions at the microscale modulate dynamics and distribution of lipids in bilayers

Mangiarotti, AgustínIcon ; Wilke, NataliaIcon
Fecha de publicación: 02/2017
Editorial: Royal Society of Chemistry
Revista: Soft Matter
ISSN: 1744-683X
e-ISSN: 1744-6848
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

For decades, it has been assumed that electrostatic long-range (micron distances) repulsions in lipid bilayers are negligible due to screening from the aqueous milieu. This concept, mostly derived from theoretical calculations, is broadly accepted in the biophysical community. Here we present experimental evidence showing that domain-domain electrostatic repulsions in charged and also in neutral lipid bilayers regulate the diffusion, in-plane structuring and merging of lipid domains in the micron range. All the experiments were performed on both, lipid monolayers and bilayers, and the remarkable similarity in the results found in bilayers compared to monolayers led us to propose that inter-domain repulsions occur mainly within the plane of the membrane. Finally, our results indicate that electrostatic interactions between the species inserted in a cell membrane are not negligible, not only at nanometric but also at larger distances, suggesting another manner for regulating the membrane properties.
Palabras clave: Electrostatics , Bilayers , Diffusion , Repulsion
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/57508
URL: http://pubs.rsc.org/en/Content/ArticleLanding/2017/SM/C6SM01957A#!divAbstract
DOI: http://dx.doi.org/10.1039/c6sm01957a
Colecciones
Articulos(CIQUIBIC)
Articulos de CENTRO DE INVEST.EN QCA.BIOL.DE CORDOBA (P)
Citación
Mangiarotti, Agustín; Wilke, Natalia; Electrostatic interactions at the microscale modulate dynamics and distribution of lipids in bilayers; Royal Society of Chemistry; Soft Matter; 13; 3; 2-2017; 686-694
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