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dc.contributor.author
Cole, Joanne B.
dc.contributor.author
Manyama, Mange F.
dc.contributor.author
Nikitovic, Dejana
dc.contributor.author
Gonzalez, Paula Natalia
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Liberton, Denise
dc.contributor.author
Wilson, Warren M.
dc.contributor.author
Rolian, Campbell
dc.contributor.author
Larson, Jacinda R.
dc.contributor.author
Kimwaga, Emmanuel
dc.contributor.author
Mathayo, Joshua
dc.contributor.author
Roseman, Charles C.
dc.contributor.author
Santorico, Stephanie A.
dc.contributor.author
Lukowiak, Ken
dc.contributor.author
Spritz, Richard A.
dc.contributor.author
Hallgrimsson, Benedikt
dc.date.available
2018-08-28T22:19:11Z
dc.date.issued
2018-02
dc.identifier.citation
Cole, Joanne B.; Manyama, Mange F.; Nikitovic, Dejana; Gonzalez, Paula Natalia; Liberton, Denise; et al.; Facial shape manifestations of growth faltering in Tanzanian children; Wiley Blackwell Publishing, Inc; Journal of Anatomy; 232; 2; 2-2018; 250-262
dc.identifier.issn
0021-8782
dc.identifier.uri
http://hdl.handle.net/11336/57469
dc.description.abstract
Variation in the shape of the human face and in stature is determined by complex interactions between genetic and environmental influences. One such environmental influence is malnourishment, which can result in growth faltering, usually diagnosed by means of comparing an individual's stature with a set of age-appropriate standards. These standards for stature, however, are typically ascertained in groups where people are at low risk for growth faltering. Moreover, genetic differences among populations with respect to stature are well established, further complicating the generalizability of stature-based diagnostic tools. In a large sample of children aged 5–19 years, we obtained high-resolution genomic data, anthropometric measures and 3D facial images from individuals within and around the city of Mwanza, Tanzania. With genome-wide complex trait analysis, we partitioned genetic and environmental variance for growth outcomes and facial shape. We found that children with growth faltering have faces that look like those of older and taller children, in a direction opposite to the expected allometric trajectory, and in ways predicted by the environmental portion of covariance at the community and individual levels. The environmental variance for facial shape varied subtly but significantly among communities, whereas genetic differences were minimal. These results reveal that facial shape preserves information about exposure to undernourishment, with important implications for refining assessments of nutritional status in children and the developmental-genetics of craniofacial variation alike.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Childhood Growth
dc.subject
Complex Traits
dc.subject
Craniofacial
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Facial Imaging
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Growth Faltering
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Facial shape manifestations of growth faltering in Tanzanian children
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-28T18:44:43Z
dc.journal.volume
232
dc.journal.number
2
dc.journal.pagination
250-262
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Cole, Joanne B.. University of Colorado; Estados Unidos
dc.description.fil
Fil: Manyama, Mange F.. Weill‐Cornell Medicine; Qatar. Catholic University of Health and Allied Sciences; Tanzania
dc.description.fil
Fil: Nikitovic, Dejana. University of Calgary; Canadá
dc.description.fil
Fil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad En Red El Cruce Dr. Nestor Carlos Kirchner Samic. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos.; Argentina
dc.description.fil
Fil: Liberton, Denise. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Wilson, Warren M.. University of Calgary; Canadá
dc.description.fil
Fil: Rolian, Campbell. University of Calgary; Canadá
dc.description.fil
Fil: Larson, Jacinda R.. University of Calgary; Canadá
dc.description.fil
Fil: Kimwaga, Emmanuel. Catholic University of Health and Allied Sciences; Tanzania
dc.description.fil
Fil: Mathayo, Joshua. Catholic University of Health and Allied Sciences; Tanzania
dc.description.fil
Fil: Roseman, Charles C.. University of Illinois at Urbana; Estados Unidos
dc.description.fil
Fil: Santorico, Stephanie A.. University of Colorado; Estados Unidos
dc.description.fil
Fil: Lukowiak, Ken. University of Calgary; Canadá
dc.description.fil
Fil: Spritz, Richard A.. University of Colorado; Estados Unidos
dc.description.fil
Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá
dc.journal.title
Journal of Anatomy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/joa.12748
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/joa.12748


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