Mostrar el registro sencillo del ítem
dc.contributor.author
Fujie, Hitomi
dc.contributor.author
Villena, Julio Cesar
dc.contributor.author
Tohno, Masanori
dc.contributor.author
Morie, Kyoko
dc.contributor.author
Shimazu, Tomoyuki
dc.contributor.author
Aso, Hisashi
dc.contributor.author
Suda, Yoshihito
dc.contributor.author
Shimosato, Takeshi
dc.contributor.author
Iwabuchi, Noriyuki
dc.contributor.author
Xiao, Jin-Zhong
dc.contributor.author
Yaeshima, Tomoko
dc.contributor.author
Iwatsuki, Keiji
dc.contributor.author
Saito, Tadao
dc.contributor.author
Numasaki, Muneo
dc.contributor.author
Kitazawa, Haruki
dc.date.available
2018-08-28T21:49:06Z
dc.date.issued
2011-10-01
dc.identifier.citation
Fujie, Hitomi; Villena, Julio Cesar; Tohno, Masanori; Morie, Kyoko; Shimazu, Tomoyuki; et al.; Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: Finding new anti-inflammatory immunobiotics; Wiley Blackwell Publishing, Inc; Fems Immunology And Medical Microbiology; 63; 1; 1-10-2011; 129-139
dc.identifier.issn
0928-8244
dc.identifier.uri
http://hdl.handle.net/11336/57452
dc.description.abstract
A total of 23 strains of bifidobacteria taxonomically belonging to five species were tested for their potent immunomodulatory effect using a combination of two methods: the NF-κB-reporter assay using a toll-like receptor 2-expressing transfectant (HEK pTLR2 system) and the mitogenic assay using porcine Peyer's patches immunocompetent cells. Among the four preselected strains from different immunomodulatory groups, Bifidobacterium breve MCC-117 was able to efficiently modulate the inflammatory response triggered by enterotoxigenic Escherichia coli (ETEC) in a porcine intestinal epithelial (PIE) cell line. Moreover, using PIE cells and swine Peyer's patches immunocompetent cell co-culture system, we demonstrated that the immunoregulatory effect of B. breve MCC-117 was related to the capacity of the strain to influence PIE and immune cell interactions, leading to the stimulation of regulatory T cells. The results suggested that bifidobacteria that express high activity in both the HEK pTLR2 and the mitogenic assays may behave like potential anti-inflammatory strains. The combination of the HEK pTLR2 system, the evaluation of mitogenic activity and PIE cells will be of value for the development of new immunologically functional foods and feeds that could prevent inflammatory intestinal disorders. Although our findings should be proven in appropriate experiments in vivo, the results of the present work provide a scientific rationale for the use of B. breve MCC-117 to prevent ETEC-induced intestinal inflammation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Anti-Inflammatory Bifidobacteria
dc.subject
Intestinal Inflammation
dc.subject
Porcine Intestinal Epithelila Cells
dc.subject
Tlr-2 Activation
dc.subject.classification
Otras Biotecnología Agropecuaria
dc.subject.classification
Biotecnología Agropecuaria
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: Finding new anti-inflammatory immunobiotics
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-05T18:42:22Z
dc.identifier.eissn
1574-695X
dc.journal.volume
63
dc.journal.number
1
dc.journal.pagination
129-139
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Fujie, Hitomi. Tohoku University; Japón
dc.description.fil
Fil: Villena, Julio Cesar. Tohoku University; Japón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Tohno, Masanori. National Agricultural Research Organization. National Institute of Livestock and Grassland Science. Functional Feed Research Team; Japón
dc.description.fil
Fil: Morie, Kyoko. Tohoku University; Japón
dc.description.fil
Fil: Shimazu, Tomoyuki. Tohoku University; Japón
dc.description.fil
Fil: Aso, Hisashi. Tohoku University; Japón
dc.description.fil
Fil: Suda, Yoshihito. Miyagi University; Japón
dc.description.fil
Fil: Shimosato, Takeshi. Shinshu University; Japón
dc.description.fil
Fil: Iwabuchi, Noriyuki. Morinaga Milk Industry Co. Ltd. Food Science and Technology Institute; Japón
dc.description.fil
Fil: Xiao, Jin-Zhong. Morinaga Milk Industry Co. Ltd. Food Science and Technology Institute; Japón
dc.description.fil
Fil: Yaeshima, Tomoko. Morinaga Milk Industry Co. Ltd. Food Science and Technology Institute; Japón
dc.description.fil
Fil: Iwatsuki, Keiji. Morinaga Milk Industry Co. Ltd. Food Science and Technology Institute; Japón
dc.description.fil
Fil: Saito, Tadao. Tohoku University; Japón
dc.description.fil
Fil: Numasaki, Muneo. Josai University; Japón
dc.description.fil
Fil: Kitazawa, Haruki. Tohoku University; Japón
dc.journal.title
Fems Immunology And Medical Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1574-695X.2011.00837.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femspd/article/63/1/129/549169
Archivos asociados