Artículo
Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs
Asuaje, Agustín
; Martín, Pedro
; Enrique, Nicolás Jorge
; Díaz Zegarra, Leandro Agustín; Smaldini, Paola Lorena
; Docena, Guillermo H.
; Milesi, Verónica
Fecha de publicación:
05/2017
Editorial:
Taylor & Francis
Revista:
Channels
ISSN:
1933-6950
e-ISSN:
1933-6969
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
An established characteristic of neoplastic cells is their metabolic reprogramming, known as the Warburg effect, with greater reliance on energetically less efficient pathways (such as glycolysis and pentose phosphate shunt) compared with oxidative phosphorylation. This results in an overproduction of acidic species that must be extruded to maintain intracellular homeostasis. We recently described that blocking the proton currents in leukemic cells mediated by Hv1 ion channels triggers a marked intracellular acidification and apoptosis induction. Moreover, histamine H1-receptor antagonists were found to induce apoptosis in tumoral cells but the mechanism is still unclear. By using Jurkat T cells, we now show how diphenhydramine inhibits Hv1 mediated currents, inducing a drop in intracellular pH and cellular viability. This provides evidence of a new target structure responsible of the known pro-apoptotic action of antihistaminic drugs.
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Articulos(IIFP)
Articulos de INST. DE ESTUDIOS INMUNOLOGICOS Y FISIOPATOLOGICOS
Articulos de INST. DE ESTUDIOS INMUNOLOGICOS Y FISIOPATOLOGICOS
Citación
Asuaje, Agustín; Martín, Pedro; Enrique, Nicolás Jorge; Díaz Zegarra, Leandro Agustín; Smaldini, Paola Lorena; et al.; Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs; Taylor & Francis; Channels; 12; 1; 5-2017; 58-64
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