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dc.contributor.author
de Moreno, Maria Alejandra
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dc.contributor.author
Perdigon, Gabriela del Valle
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dc.date.available
2018-08-27T20:07:24Z
dc.date.issued
2005-04
dc.identifier.citation
de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle; Reduction of β-Glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model; Sociedad Latinoamericana de Microscopía Electrónica; Centro Regional de Investigaciones Científicas y Tecnológicas; Biocell; 29; 1; 4-2005; 15-24
dc.identifier.issn
0327-9545
dc.identifier.uri
http://hdl.handle.net/11336/57290
dc.description.abstract
Yoghurt feeding inhibits induced colon cancer in mice. Several studies showed the immunomodulatory effect of yoghurt which can explain this inhibition. It is possible that yoghurt bacteria can also affect gut flora enzymes related to colon carcinogenesis as reported for other probiotics in different animal tumours. The aim of this work was to evaluate the role of yoghurt starter bacteria and their cell-free fermentation products on the reduction of procarcinogen enzyme activities (β-glucuronidase and nitroreductase). Mice injected with 1,2-dimethylhydrazine (DMH) and fed with yoghurt were used for this study. Mice given milk or yoghurt supernatant (cell free extract) were used to evaluate if the yoghurt antitumour effect is due to the starter bacteria or other components released during fermentation, that could inhibit these enzymes. We determined that yoghurt by itself maintained enzymes activities similar or lower than nontreatment control group, and the enzyme activity was also lower than milk or yoghurt supernatant groups. DMH increased the activity of the enzymes. Mice injected with DMH and fed cyclically with yoghurt presented lower enzymes activities than the tumour control group. Feeding yoghurt decreased procarcinogenic enzyme levels in the large intestine contents of mice bearing colon tumour. The results of this study provide another mechanism by which yoghurt starter bacteria interact with the large intestine of the mice and prevent colon cancer.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sociedad Latinoamericana de Microscopía Electrónica; Centro Regional de Investigaciones Científicas y Tecnológicas
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Colon Cancer
dc.subject
Yoghurt
dc.subject
Strater Bacteria
dc.subject
B-Glucuronidase
dc.subject
Nitroreductase
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Reduction of β-Glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-21T14:03:37Z
dc.identifier.eissn
1667-5746
dc.journal.volume
29
dc.journal.number
1
dc.journal.pagination
15-24
dc.journal.pais
Argentina
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dc.journal.ciudad
Mendoza
dc.description.fil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.journal.title
Biocell
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/4sptch
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