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dc.contributor.author
Ponssa, María Laura
dc.contributor.author
Abdala, Virginia Sara Luz
dc.date.available
2018-08-23T18:26:01Z
dc.date.issued
2016-03
dc.identifier.citation
Ponssa, María Laura; Abdala, Virginia Sara Luz; Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case; PeerJ Inc.; PeerJ; 2016; 2; 3-2016; 1-18
dc.identifier.issn
2167-8359
dc.identifier.uri
http://hdl.handle.net/11336/56848
dc.description.abstract
Movement is one of the most important epigenetic factors for normal development of the musculoskeletal system, particularly during genesis and joint development. Studies regarding alterations to embryonic mobility, performed on anurans, chickens and mammals, report important phenotypical similarities as a result of the reduction or absence of this stimulus. The precise stage of development at which the stimulus modification generates phenotypic modifications however, is yet to be determined. In this work we explore whether the developmental effects of abnormal mobility can appear at any time during development or whether they begin to express themselves in particular phases of tadpole ontogeny. We conducted five experiments that showed that morphological abnormalities are not visible until Stages 40-42. Morphology in earlier stages remains normal, probably due to the fact that the bones/muscles/tendons have not yet developed and therefore are not affected by immobilization. These results suggest the existence of a specific period of phenotypical expression in which normal limb movement is necessary for the correct development of the joint tissue framework.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
PeerJ Inc.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Anurans
dc.subject
Development
dc.subject
Knee-Joint
dc.subject
Phenotypical Expression
dc.subject
Reduced Mobility
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-17T16:56:37Z
dc.journal.volume
2016
dc.journal.number
2
dc.journal.pagination
1-18
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Ponssa, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; Argentina
dc.description.fil
Fil: Abdala, Virginia Sara Luz. Universidad Nacional de Tucuman. Facultad de Ciencias Naturales E Instituto Miguel Lillo. Cátedra de Biología General; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
PeerJ
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.7717/peerj.1730
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://peerj.com/articles/1730/


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