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dc.contributor.author
Golemba, Marcelo Darío
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dc.contributor.author
Culasso, Andrés Carlos Alberto
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dc.contributor.author
Villamil, Federico
dc.contributor.author
Baré, Patricia
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dc.contributor.author
Gadano, Adrián Carlos
dc.contributor.author
Ridruejo, Ezequiel
dc.contributor.author
Martínez, Alfredo
dc.contributor.author
Di Lello, Federico Alejandro
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dc.contributor.author
Campos, Rodolfo Hector
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dc.date.available
2015-05-26T19:40:22Z
dc.date.issued
2013-12-30
dc.identifier.citation
Golemba, Marcelo Darío; Culasso, Andrés Carlos Alberto; Villamil, Federico; Baré, Patricia; Gadano, Adrián Carlos; Ridruejo, Ezequiel; Martínez, Alfredo; Di Lello, Federico Alejandro; Campos, Rodolfo Hector; Hepatitis C Virus Diversification in Argentina: Comparative Analysis between the Large City of Buenos Aires and the Small Rural Town of O’Brien; Public Library Science; Plos One; 8; 30-12-2013; 1-8;
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/567
dc.description.abstract
The estimated prevalence of HCV infection in Argentina is around 2%. However, higher rates of infection have been described in population studies of small urban and rural communities. The aim of this work was to compare the origin and diversification of HCV-1b in samples from two different epidemiological scenarios: Buenos Aires, a large cosmopolitan city, and O´Brien, a small rural town with a high prevalence of HCV infection. PATIENTS AND METHODS: The E1/E2 and NS5B regions of the viral genome from 83 patients infected with HCV-1b were sequenced. Phylogenetic analysis and Bayesian Coalescent methods were used to study the origin and diversification of HCV-1b in both patient populations. RESULTS: Samples from Buenos Aires showed a polyphyletic behavior with a tMRCA around 1887-1900 and a time of spread of infection approximately 60 years ago. In contrast, samples from ÓBrien showed a monophyletic behavior with a tMRCA around 1950-1960 and a time of spread of infection more recent than in Buenos Aires, around 20-30 years ago. CONCLUSION: Phylogenetic and coalescence analysis revealed a different behavior in the epidemiological histories of Buenos Aires and ÓBrien. HCV infection in Buenos Aires shows a polyphyletic behavior and an exponential growth in two phases, whereas that in O´Brien shows a monophyletic cluster and an exponential growth in one single step with a more recent tMRCA. The polyphyletic origin and the probability of encountering susceptible individuals in a large cosmopolitan city like Buenos Aires are in agreement with a longer period of expansion. In contrast, in less populated areas such as O´Brien, the chances of HCV transmission are strongly restricted. Furthermore, the monophyletic character and the most recent time of emergence suggest that different HCV-1b ancestors (variants) that were in expansion in Buenos Aires had the opportunity to colonize and expand in O´Brien.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hcv
dc.subject
Quasispecies
dc.subject
Diversification
dc.subject.classification
Ciencias Médicas y de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
Enfermedades Infecciosas
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dc.title
Hepatitis C Virus Diversification in Argentina: Comparative Analysis between the Large City of Buenos Aires and the Small Rural Town of O’Brien
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
8
dc.journal.pagination
1-8
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Golemba, Marcelo Darío. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Microbiologia,inmunologia y Biotecnolog.;
dc.description.fil
Fil: Culasso, Andrés Carlos Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Microbiologia,inmunologia y Biotecnolog.. Cat. de Virologia;
dc.description.fil
Fil: Villamil, Federico. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad En Red El Cruce Dr. Nestor Carlos Kirchner Samic;
dc.description.fil
Fil: Baré, Patricia. Consejo Nacional de Invest.cientif.y Tecnicas. Instituto de Medicina Experimental;
dc.description.fil
Fil: Gadano, Adrián Carlos. Htal.italiano;
dc.description.fil
Fil: Ridruejo, Ezequiel. Centro de Educaciones Medicas E Investig.clinica "norberto Quirno";
dc.description.fil
Fil: Martínez, Alfredo. Centro de Educaciones Medicas E Investig.clinica "norberto Quirno";
dc.description.fil
Fil: Di Lello, Federico Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Microbiologia,inmunologia y Biotecnolog.. Cat. de Virologia;
dc.description.fil
Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Microbiologia,inmunologia y Biotecnolog.;
dc.journal.title
Plos One
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0084007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/24386322
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