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dc.contributor.author
Corchuelo, Sheryll
dc.contributor.author
Martinez, Emanuel R. M.
dc.contributor.author
Butzge, Arno J.
dc.contributor.author
Doretto, Lucas B.
dc.contributor.author
Ricci, Juliana M.B.
dc.contributor.author
Valentin, Fernanda N.
dc.contributor.author
Nakaghi, Laura S.O.
dc.contributor.author
Somoza, Gustavo Manuel
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dc.contributor.author
Nóbrega, Rafael H.
dc.date.available
2018-08-22T14:22:07Z
dc.date.issued
2017-07
dc.identifier.citation
Corchuelo, Sheryll; Martinez, Emanuel R. M.; Butzge, Arno J.; Doretto, Lucas B.; Ricci, Juliana M.B.; et al.; Characterization of Gnrh/Gnih elements in the olfacto-retinal system and ovary during zebrafish ovarian maturation; Elsevier Ireland; Molecular and Cellular Endocrinology; 450; 7-2017; 1-13
dc.identifier.issn
0303-7207
dc.identifier.uri
http://hdl.handle.net/11336/56523
dc.description.abstract
Gonadotropin releasing hormone (GnRH) is one of the key players of brain-pituitary-gonad axis, exerting overall control over vertebrate reproduction. In zebrafish, two variants were characterized and named as Gnrh2 and Gnrh3. In this species, Gnrh3, the hypohysiotropic form, is expressed by neurons of the olfactory-retinal system, where it is related with food detection, intra/interspecific recognition, visual acuity and retinal processing modulation. Previous studies have reported the presence of Gnrh receptors in the zebrafish retina, but not yet in the zebrafish olfactory epithelium. The current study analyzed the presence of gnrh2 and gnrh3, their receptors (gnrhr 1,2,3 and 4) and gnih (gonadotropin inhibitory hormone) transcripts, as well as the Gnrh3 protein in the olfactory epithelium (OE), olfactory bulb (OB), retina and ovary during zebrafish ovarian maturation. We found an increase of gnrh receptors transcripts in the OE at the final stages of ovarian maturation. In the OE, Gnrh3 protein was detected in the olfactory receptor neurons cilia and in the olfactory nerve fibers. Interestingly, in the OB, we found an inverse expression pattern between gnih and gnrh3. In the retina, gnrhr4 mRNA was found in the nuclei of amacrine, bipolar, and ganglion cells next to Gnrh3 positive fibers. In the ovary, gnrh3, gnrhr2 and gnrhr4 transcripts were found in perinucleolar oocytes, while gnih in oocytes at the cortical alveolus stage. Our results suggested that Gnrh/Gnih elements are involved in the neuromodulation of the sensorial system particularly at the final stages of maturation, playing also a paracrine role in the ovary.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gnih
dc.subject
Gnrh
dc.subject
Olfactory Bulb
dc.subject
Ovarian Maturation
dc.subject
Sensorial Systems
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Zebrafish
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Characterization of Gnrh/Gnih elements in the olfacto-retinal system and ovary during zebrafish ovarian maturation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-21T18:39:11Z
dc.journal.volume
450
dc.journal.pagination
1-13
dc.journal.pais
Irlanda
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dc.journal.ciudad
Limerick
dc.description.fil
Fil: Corchuelo, Sheryll. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Martinez, Emanuel R. M.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Butzge, Arno J.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Doretto, Lucas B.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Ricci, Juliana M.B.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Valentin, Fernanda N.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Nakaghi, Laura S.O.. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Somoza, Gustavo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
dc.description.fil
Fil: Nóbrega, Rafael H.. Universidade de Sao Paulo; Brasil
dc.journal.title
Molecular and Cellular Endocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.mce.2017.04.002
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720717302150
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