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dc.contributor.author
de Moreno, Maria Alejandra
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dc.contributor.author
Perdigon, Gabriela del Valle
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dc.date.available
2018-08-21T21:58:14Z
dc.date.issued
2004-04
dc.identifier.citation
de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle; Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer; International Scientific Information, Inc.; Medical Science Monitor; 10; 4; 4-2004; 96-104
dc.identifier.issn
1234-1010
dc.identifier.uri
http://hdl.handle.net/11336/56507
dc.description.abstract
Background: In BALB/c mice, a yogurt diet given before and after the carcinogen 1, 2 dymethylhydrazine (DMH) inhibited colon cancer. This paper studied at which stage of tumor development (initiation, promotion or progression) yogurt exerts its antitumor activity. Material/Methods: Six experimental groups were used: 1) non-treatment control; 2) DMH control; 3) yogurt- DMH-yogurt: yogurt administered before and after DMH. 4) yogurt-DMH: yogurt given only 10 days before DMH; 5) DMH-yogurt: yogurt given cyclically after DMH; and 6) yogurt control. The groups DMH-yogurt and yogurt-DMH were compared histologically and TNFα, INFγ, IL-10 and IL-4 cytokines, CD4[sup]+[/sup]/CD25[sup]+[/sup] T cells, and apoptotic cells were determined in large intestine biopsies. TNFα and INFγ were also determined in cells isolated from large intestine nodules and from Peyer’s patches. Results: The DMH-yogurt group did not develop tumor. The yogurt-DMH group showed only tumor delay; TNFα, INFγ and IL-10 increasing in this group in all the periods assayed. These results agree with those already reported for DMH control and yogurt-DMH-yogurt. There was no correlation between the high levels of IL-10 and CD4[sup]+[/sup]/CD25+ T regulatory population. IL-4 and apoptotic cells increased in the yogurt-DMH group only in the first months. In the DMHyogurt group, cellular apoptosis increased during the whole treatment. Yogurt feeding induced TNFα and INFγ increases in cells isolated from large intestine nodules. These cytokines also increased in cells from Peyer’s patches of the yogurt control group. Conclusions: These results show that yogurt inhibited tumor progression and promotion by modulating the immune response and stimulating cellular apoptosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
International Scientific Information, Inc.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Yoghurt
dc.subject
Colon Cancer
dc.subject
Immune Response
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-21T14:05:41Z
dc.identifier.eissn
1643-3750
dc.journal.volume
10
dc.journal.number
4
dc.journal.pagination
96-104
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Smithtown
dc.description.fil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.journal.title
Medical Science Monitor
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.medscimonit.com/download/index/idArt/11626
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