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dc.contributor.author
de Moreno, Maria Alejandra
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dc.contributor.author
Leblanc, Jean Guy Joseph
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dc.contributor.author
Perdigon, Gabriela del Valle
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dc.contributor.author
Miyoshi, Anderson
dc.contributor.author
Langella, Philippe
dc.contributor.author
Azevedo, Vaso
dc.contributor.author
Sesma, Fernando Juan Manuel
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dc.date.available
2018-08-21T21:17:10Z
dc.date.issued
2008-01
dc.identifier.citation
de Moreno, Maria Alejandra; Leblanc, Jean Guy Joseph; Perdigon, Gabriela del Valle; Miyoshi, Anderson; Langella, Philippe; et al.; Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice; Society for General Microbiology; Journal Of Medical Microbiology; 57; 1; 1-2008; 100-105
dc.identifier.issn
0022-2615
dc.identifier.uri
http://hdl.handle.net/11336/56483
dc.description.abstract
Reactive oxygen species, such as hydrogen peroxide (H2O 2), are involved in various aspects of tumour development. Decreasing their levels can therefore be a promising approach for colon cancer prevention. The objective of this study was to evaluate the effect of catalase-producing Lactococcus lactis on the prevention of an experimental murine 1,2-dimethylhydrazine (DMH)-induced colon cancer. DMH-treated BALB/c mice received either a catalase-producing L. lactis strain or the isogenic non-catalase-producing strain as a control, whereas other untreated mice did not receive bacterial supplementation. Catalase activity and H2O 2 levels in intestinal fluids and blood samples were measured, and changes in the histology of the large intestines during tumour progression were evaluated. The catalase-producing L. lactis strain used in this study was able to slightly increase catalase activities in DMH-treated mice (1.19 ± 0.08 U ml-1) and reduce H2O2 levels (3.4 ± 1.1 μM) compared to (i) animals that received the non-catalase-producing strain (1.00 ± 0.09 U ml-1, 9.0 ± 0.8 μM), and (ii) those that did not receive bacterial supplementation (1.06 ± 0.07 U ml-1, 10.0 ± 1.1 μM). Using the histopathological grading scale of chemically induced colorectal cancer, animals that received the catalase-producing L. lactis had a significantly lesser extent of colonic damage and inflammation (2.0 ± 0.4) compared to animals that received the non-catalase-producing L. lactis (4.0 ± 0.3) or those that did not receive bacterial supplementation (4.7 ± 0.5). The catalase-producing L. lactis strain used in this study was able to prevent tumour appearance in an experimental DMH-induced colon cancer model.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for General Microbiology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Catalase
dc.subject
Lactic Acid Bacteria
dc.subject
Colon Cancer
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-23T18:14:09Z
dc.identifier.eissn
1473-5644
dc.journal.volume
57
dc.journal.number
1
dc.journal.pagination
100-105
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Miyoshi, Anderson. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia
dc.description.fil
Fil: Azevedo, Vaso. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: Sesma, Fernando Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.journal.title
Journal Of Medical Microbiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1099/jmm.0.47403-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47403-0
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