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dc.contributor.author
Rey, Rodolfo Alberto
dc.date.available
2018-08-17T15:05:05Z
dc.date.issued
2017-09
dc.identifier.citation
Rey, Rodolfo Alberto; Commentary on sperm DNA fragmentation testing clinical guideline; AME Publishing Company; Translational Andrology and Urology; 6; suppl 4; 9-2017; S522-S524
dc.identifier.issn
2223-4691
dc.identifier.uri
http://hdl.handle.net/11336/56093
dc.description.abstract
The study of physiology of reproduction, particularly in mammalian species, experienced glorious times in the second half of the twentieth century. However, with the advent of intracytoplasmic sperm injection (ICSI), the decade of 1990 appeared to forecast the demise of translational research in male reproductive biology. In fact, in its original and subsequent work, Palermo and colleagues showed that ICSI bypassed the process of natural selection of sperm (1). Then, the prevailing hope became that the only need would be merely to obtain one acceptable spermatozoon. The optimism, based on an exponential increase of successful results, has been moderated in the last decade by results indicating that certain sperm characteristics have an impact on the outcomes of assisted reproduction (2). Recent basic research findings have radically transformed our understanding of the biology of fertilization (3), underscoring the importance of cytological processes, e.g. the timing of sperm acrosomal exocytosis (4), in addition to sperm-associated epigenetic factors (5), proteomics (6) and DNA structure (7,8).
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
AME Publishing Company
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sperm
dc.subject
Dna
dc.subject.classification
Medicina Critica y de Emergencia
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Commentary on sperm DNA fragmentation testing clinical guideline
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-16T15:10:31Z
dc.identifier.eissn
2223-4683
dc.journal.volume
6
dc.journal.number
suppl 4
dc.journal.pagination
S522-S524
dc.journal.pais
China
dc.journal.ciudad
Hong Kong
dc.description.fil
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas ; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title
Translational Andrology and Urology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://tau.amegroups.com/article/view/14038/17090
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.21037/tau.2017.03.19


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