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dc.contributor.author Rey, Rodolfo Alberto
dc.date.available 2018-08-17T15:05:05Z
dc.date.issued 2017-09
dc.identifier.citation Rey, Rodolfo Alberto; Commentary on sperm DNA fragmentation testing clinical guideline; AME Publishing Company; Translational Andrology and Urology; 6; suppl 4; 9-2017; S522-S524
dc.identifier.issn 2223-4691
dc.identifier.uri http://hdl.handle.net/11336/56093
dc.description.abstract The study of physiology of reproduction, particularly in mammalian species, experienced glorious times in the second half of the twentieth century. However, with the advent of intracytoplasmic sperm injection (ICSI), the decade of 1990 appeared to forecast the demise of translational research in male reproductive biology. In fact, in its original and subsequent work, Palermo and colleagues showed that ICSI bypassed the process of natural selection of sperm (1). Then, the prevailing hope became that the only need would be merely to obtain one acceptable spermatozoon. The optimism, based on an exponential increase of successful results, has been moderated in the last decade by results indicating that certain sperm characteristics have an impact on the outcomes of assisted reproduction (2). Recent basic research findings have radically transformed our understanding of the biology of fertilization (3), underscoring the importance of cytological processes, e.g. the timing of sperm acrosomal exocytosis (4), in addition to sperm-associated epigenetic factors (5), proteomics (6) and DNA structure (7,8).
dc.format application/pdf
dc.language.iso eng
dc.publisher AME Publishing Company
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Sperm
dc.subject DNA
dc.subject.classification Medicina Critica y de Emergencia
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Commentary on sperm DNA fragmentation testing clinical guideline
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-08-16T15:10:31Z
dc.identifier.eissn 2223-4683
dc.journal.volume 6
dc.journal.number suppl 4
dc.journal.pagination S522-S524
dc.journal.pais China
dc.journal.ciudad Hong Kong
dc.description.fil Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas ; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title Translational Andrology and Urology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://tau.amegroups.com/article/view/14038/17090
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.21037/tau.2017.03.19
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)