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dc.contributor.author
Trolle, Thomas  
dc.contributor.author
McMurtrey, Curtis  
dc.contributor.author
Sidney, John  
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Bardet, Wilfried  
dc.contributor.author
Osborn, Sean C.  
dc.contributor.author
Kaever, Thomas  
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Sette, Alessandro  
dc.contributor.author
Hildebrand, Willliam H.  
dc.contributor.author
Nielsen, Morten  
dc.contributor.author
Peters, Bjoern  
dc.date.available
2018-08-16T18:51:11Z  
dc.date.issued
2016-02  
dc.identifier.citation
Trolle, Thomas; McMurtrey, Curtis; Sidney, John; Bardet, Wilfried; Osborn, Sean C.; et al.; The length distribution of class I-restricted T cell epitopes is determined by both peptide supply and MHC allele-specific binding preference; American Association of Immunologists; Journal of Immunology; 196; 4; 2-2016; 1480-1487  
dc.identifier.issn
0022-1767  
dc.identifier.uri
http://hdl.handle.net/11336/55981  
dc.description.abstract
HLA class I-binding predictions are widely used to identify candidate peptide targets of human CD8+ T cell responses. Many such approaches focus exclusively on a limited range of peptide lengths, typically 9 aa and sometimes 9-10 aa, despite multiple examples of dominant epitopes of other lengths. In this study, we examined whether epitope predictions can be improved by incorporating the natural length distribution of HLA class I ligands. We found that, although different HLA alleles have diverse length-binding preferences, the length profiles of ligands that are naturally presented by these alleles are much more homogeneous. We hypothesized that this is due to a defined length profile of peptides available for HLA binding in the endoplasmic reticulum. Based on this, we created a model of HLA allele-specific ligand length profiles and demonstrate how this model, in combination with HLA-binding predictions, greatly improves comprehensive identification of CD8+ T cell epitopes.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Association of Immunologists  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Mhc Class I  
dc.subject
Binding Motifs  
dc.subject.classification
Salud Ocupacional  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
The length distribution of class I-restricted T cell epitopes is determined by both peptide supply and MHC allele-specific binding preference  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-19T16:52:32Z  
dc.journal.volume
196  
dc.journal.number
4  
dc.journal.pagination
1480-1487  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Bethesda  
dc.description.fil
Fil: Trolle, Thomas. Technical University of Denmark; Dinamarca  
dc.description.fil
Fil: McMurtrey, Curtis. Oklahoma State University; Estados Unidos  
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Fil: Sidney, John. La Jolla Institute for Allergy and Immunology; Estados Unidos  
dc.description.fil
Fil: Bardet, Wilfried. Oklahoma State University; Estados Unidos  
dc.description.fil
Fil: Osborn, Sean C.. Oklahoma State University; Estados Unidos  
dc.description.fil
Fil: Kaever, Thomas. La Jolla Institute for Allergy and Immunology; Estados Unidos  
dc.description.fil
Fil: Sette, Alessandro. La Jolla Institute for Allergy and Immunology; Estados Unidos  
dc.description.fil
Fil: Hildebrand, Willliam H.. Oklahoma State University; Estados Unidos  
dc.description.fil
Fil: Nielsen, Morten. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentina. Universidad Nacional de San Martín; Argentina  
dc.description.fil
Fil: Peters, Bjoern. La Jolla Institute for Allergy and Immunology; Estados Unidos  
dc.journal.title
Journal of Immunology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4049/jimmunol.1501721  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jimmunol.org/content/196/4/1480