Artículo
The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia
Gamberale, Romina
; Fernández Calotti, Paula; Sánchez Ávalos, Julio César Américo; Alberto, Maria Fabiana; Geffner, Jorge Raúl
; Giordano, Mirta Nilda
Fecha de publicación:
12/2006
Editorial:
Ferrata Storti Foundation
Revista:
Haematologica
ISSN:
0390-6078
e-ISSN:
1592-8721
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently illdefined mechanism. We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patients to fludarabine increases in vitro production of interferon-g, a key cytokine in the pathogenesis of AHA.<br />
Palabras clave:
Fludarabine
,
Ifng Production
,
Autoimmune Hemolytic Anemia
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Colecciones
Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Citación
Gamberale, Romina; Fernández Calotti, Paula; Sánchez Ávalos, Julio César Américo; Alberto, Maria Fabiana; Geffner, Jorge Raúl; et al.; The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia; Ferrata Storti Foundation; Haematologica; 91; 4; 12-2006; 574-576
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