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Artículo

Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments

Horst, María FernandaIcon ; Coral, Diego FernandoIcon ; Fernández van Raap, Marcela BeatrizIcon ; Alvarez, MarianaIcon ; Lassalle, Verónica LeticiaIcon
Fecha de publicación: 05/2017
Editorial: Elsevier Science
Revista: Materials Science and Engineering: C
ISSN: 0928-4931
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Nano-materiales

Resumen

In this study, one–step co-precipitation method was conveniently adapted to obtain novel nanomaterials based on Gum Arabic and magnetite. Two synthesis procedures were evaluated: one employing the solid biopolymer in the co-precipitation media; a second using an aqueous solution of the polysaccharide. An exhaustive characterization of both formulations was performed using several specific techniques. The obtained data confirmed the successful incorporation of the gum Arabic on the magnetic core. Values of hydrodynamic diameters, measured by dynamic light scattering, in aqueous dispersions were about 70–80 nm, while sizes lower than 20 nm were registered by TEM microscopy. Surface charge of gum Arabic coated magnetic nanoparticles was significantly different from the corresponding to raw materials (magnetite and GA). This fact confirmed the formation of hybrid nanosystems with novel and specific properties. The potential utility of these materials was tested regarding to magnetic hyperthermia therapy under radiofrequency fields. Magnetocalorimetric measurements were performed in a wide range of field amplitude and frequency. Specific absorption rate of 218 W/gFe was determined at field frequency of 260 kHz and amplitude of 52 kA/m. These results demonstrate their viability to be applied in tumor ablation treatments. Using the linear response theory and restricting field parameters to the accepted biomedical window, maximum useful value of 74 w/gFe is predicted at 417 kHz and 12 kA/m.
Palabras clave: Gum Arabic , Hyperthermia , Magnetic Nanoparticles , Magnetite
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/55811
URL: https://www.sciencedirect.com/science/article/pii/S0928493116308189
DOI: https://doi.org/10.1016/j.msec.2016.12.035
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Articulos(INQUISUR)
Articulos de INST.DE QUIMICA DEL SUR
Citación
Horst, María Fernanda; Coral, Diego Fernando; Fernández van Raap, Marcela Beatriz; Alvarez, Mariana; Lassalle, Verónica Leticia; Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments; Elsevier Science; Materials Science and Engineering: C; 74; 5-2017; 443-450
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