Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus

A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa.

Palabras clave: Triterpeno , Sulfatado , Citotoxico , Antiproliferativo

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/5555

DOI: http://dx.doi.org/ 10.1080/14786419.2012.751596

URL: http://www.tandfonline.com/doi/full/10.1080/14786419.2012.751596

DOI: http://dx.doi.org/10.1080/14786419.2012.751596

Colecciones

Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)

Citación

Careaga Quiroga, Valeria Pilar; Bueno, Carlos Alberto; Muniain, Claudia Cristina; Alche, Laura Edith; Maier, Marta Silvia; Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus; Taylor & Francis; Natural Product Research; 28; 4; 17-12-2012; 2213-220

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