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dc.contributor.author
Bibas Bonet, María Eugenia
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dc.contributor.author
Fontenla de Petrino, Silvia Estela
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dc.contributor.author
Mesón, Oscar Enrique
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dc.contributor.author
Perdigon, Gabriela del Valle
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dc.date.available
2018-08-14T19:26:53Z
dc.date.issued
2005-09
dc.identifier.citation
Bibas Bonet, María Eugenia; Fontenla de Petrino, Silvia Estela; Mesón, Oscar Enrique; Perdigon, Gabriela del Valle; Antitumour effect of Lactobacillus casei CRL 431 on different experimental tumours; Taylor & Francis; Food And Agricultural Immunology; 16; 3; 9-2005; 181-191
dc.identifier.issn
0954-0105
dc.identifier.uri
http://hdl.handle.net/11336/55473
dc.description.abstract
We analysed the mechanisms of tumour inhibition by Lactobacillus casei CRL 431 orally administered, for fibrosarcome (non intestinal tumour, NIT) and for carcinoma (intestinal tumour, IT), both induced chemically. Balb/c mice were fed with L. casei (1.2 × 109 cel/day/ mouse) for two consecutive days previous to the induction of the respective tumours. After IT induction, oral administration of L. casei was repeated cyclically every 5 days for 5 months. In order to determine the percentage of tumour inhibition in the NIT mice, morphometric studies were performed and TNFα levels in serum and spleen cells were determined. In the IT, macroscopic and histopathological studies were performed and the number of intestinal IgA+ and TNFα+ cells was determined. We demonstrated that L. casei CRL 431 inhibited the growth of both tumours. In the case of NIT animals treated with L. casei, the high levels of serum TNFα would play an important role in the inhibition of tumour growth due to its cytolytic activity against tumour cells. In the IT, the increase in IgA+ and TNFα+ cells could be involved in the inhibitory effect observed. Our results showed that the selection of the probiotic bacteria with antitumour activity would not be limited to the determination of the cytokines relevant to this activity because of the multifactorial etiology of the different cancers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Colorectal Cancer
dc.subject
Cytokines
dc.subject
Fibrosarcome
dc.subject
Lactobacillus Casei
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Antitumour effect of Lactobacillus casei CRL 431 on different experimental tumours
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-13T18:13:52Z
dc.identifier.eissn
1465-3443
dc.journal.volume
16
dc.journal.number
3
dc.journal.pagination
181-191
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Bibas Bonet, María Eugenia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Fontenla de Petrino, Silvia Estela. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Mesón, Oscar Enrique. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Perdigon, Gabriela del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.journal.title
Food And Agricultural Immunology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/09540100500173105
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09540100500173105
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