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Artículo

Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease

Beauquis, JuanIcon ; Pavía, Patricio Roberto; Pomilio, Carlos JavierIcon ; Vinuesa, María AngelesIcon ; Podlutskaya, Natalia; Galvan, Verónica; Saravia, Flavia EugeniaIcon
Fecha de publicación: 31/01/2013
Editorial: Academic Press Inc Elsevier Science
Revista: Experimental Neurology
ISSN: 0014-4886
e-ISSN: 1090-2430
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular; Neurociencias

Resumen

Alzheimer's disease (AD) is a neurodegenerative disease that affects neurons and glial cells and leads to dementia. Growing evidence shows that glial changes may precede neuronal alterations and behavioral impairment in the progression of the disease. The modulation of these changes could be addressed as a potential therapeutic strategy. Environmental enrichment has been classically associated to effects on neuronal morphology and function but less attention has been paid to the modulation of glia. We thus characterized astroglial changes in the hippocampus of adult PDAPP-J20 transgenic mice, a model of AD, exposed for 3. months to an enriched environment, from 5 to 8. months of age. Using confocal microscopy, three-dimensional reconstruction and Sholl analysis, we evaluated the morphology of two distinct populations of astrocytes: those associated to amyloid β plaques and those that were not. We found that plaque-associated astrocytes in PDAPP-J20 mice had an increased volume and process ramification than control astrocytes. Non-plaque-associated astrocytes showed a decrease in volume and an increase in the ramification of GFAP. + processes as compared with control astrocytes. Environmental enrichment prevented these alterations and promoted a cellular morphology similar to that found in control mice. Morphological changes in non-plaque-associated astrocytes were found also at 5. months of age, before amyloid β deposition in the hippocampus. These results suggest that glial alterations have an early onset in AD pathogenesis and that the exposure to an enriched environment is an appropriate strategy to reverse them. Cellular and molecular pathways involved in this regulation could constitute potential novel therapeutic targets.
Palabras clave: Alzheimer'S Disease , Astrocytes , Environmental Enrichment , Gfap , Hippocampus , Transgenic Mice
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/5547
DOI: http://dx.doi.org/10.1016/j.expneurol.2012.09.009
URL: http://www.sciencedirect.com/science/article/pii/S0014488612003718
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
Beauquis, Juan; Pavía, Patricio Roberto; Pomilio, Carlos Javier; Vinuesa, María Angeles; Podlutskaya, Natalia; et al.; Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease; Academic Press Inc Elsevier Science; Experimental Neurology; 239; 1; 31-1-2013; 28-37
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