Detailing Protein Landscapes under Pressure

Abstract

Natural protein molecules are remarkablephysical objects. Despite the astronomicalnumber of competing structuralforms, these systems self-organize intobeautiful structural ensembles in biologicallyshort timescales, puzzlingout the feat of specifically bringingtogether thousands of atoms interactingby a myriad of weak forces. Moreover,most protein domains appear to foldwith ease in a deceptively simple twostatemanner, populating either the fullyfolded or fully unfolded ensembles.This is certainly not a property ofrandom amino acid chains.how doproteins do it?