Mostrar el registro sencillo del ítem

dc.contributor.author Grinspon, Romina
dc.contributor.author Habib, Carolina
dc.contributor.author Bedecarras, Patricia Gladys
dc.contributor.author Gottlieb, Silvia Elisa
dc.contributor.author Rey, Rodolfo Alberto
dc.date.available 2018-08-14T18:38:27Z
dc.date.issued 2016-03
dc.identifier.citation Grinspon, Romina; Habib, Carolina; Bedecarras, Patricia Gladys; Gottlieb, Silvia Elisa; Rey, Rodolfo Alberto; Compensatory function of the remaining testis is dissociated in boys and adolescents with monorchidism; BioScientifica; European Journal of Endocrinology; 174; 3; 3-2016; 399-407
dc.identifier.issn 0804-4643
dc.identifier.uri http://hdl.handle.net/11336/55450
dc.description.abstract Objective: Compensatory hypertrophy has been classically described in patients with monorchidism. However, it remains unclear whether there is a functional compensatory activity of the different cell populations. Our aim was to assess the functional capacity of the solitary testis in monorchid males from infancy through puberty in order to determine whether the remaining gonad is capable of compensating the functional activity of Sertoli and Leydig cells of the absent gonad. Design: In a retrospective, cross-sectional, analytical study performed at a tertiary paediatric public hospital, we included 89 boys with monorchidism and 358 healthy controls, aged 6 months-18 years. Testicular volume and circulating levels of reproductive hormones were compared between patients with monorchidism and normal boys. Serum anti-Mullerian hormone (AMH) and FSH were used as biomarkers of the functional mass of prepubertal Sertoli cells, whereas serum testosterone and LH were used as biomarkers of Leydig cells. Results: In the vast majority of the cases, the testicular volume of monorchid boys was smaller than the sum of the volume of both testes of healthy controls. Serum AMH was lower and FSH was higher in patients with monorchidism than in controls aged <3 and >13 years. Serum testosterone and LH did not differ significantly between patients and controls. Conclusion: In boys and adolescents with monorchidism, there is a dissociated capacity of the remaining testis to compensate for the absence of the other gonad: while Leydig cell function is largely compensated, Sertoli cell proliferation and function was lower than in controls.
dc.format application/pdf
dc.language.iso eng
dc.publisher BioScientifica
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Monorchidism
dc.subject Sertoli cell
dc.subject Hipogonadism
dc.subject.classification Medicina Critica y de Emergencia
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Compensatory function of the remaining testis is dissociated in boys and adolescents with monorchidism
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-07-05T13:37:39Z
dc.identifier.eissn 1479-683X
dc.journal.volume 174
dc.journal.number 3
dc.journal.pagination 399-407
dc.journal.pais Reino Unido
dc.journal.ciudad Bristol
dc.description.fil Fil: Grinspon, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas ; Argentina
dc.description.fil Fil: Habib, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas ; Argentina
dc.description.fil Fil: Bedecarras, Patricia Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas ; Argentina
dc.description.fil Fil: Gottlieb, Silvia Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas ; Argentina
dc.description.fil Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas ; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title European Journal of Endocrinology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.eje-online.org/content/174/3/399
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1530/EJE-15-0938
dc.conicet.fuente unificacion


Archivos asociados

Aparece en la(s) siguiente(s) colección(ones)

  • Articulos(CEDIE) [99]
    Articulos de CENTRO DE INVESTIGACIONES ENDOCRINOLOGICAS "DR. CESAR BERGADA"

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)